Balamurali Deepak, Stoll Monika
Genetic Epidemiology and Statistical Genetics, Department of Biochemistry, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, The Netherlands.
Institute of Human Genetics, Genetic Epidemiology, University of Muenster, 48149 Muenster, Germany.
Noncoding RNA. 2020 Sep 2;6(3):35. doi: 10.3390/ncrna6030035.
Cardiovascular diseases (CVDs) are of multifactorial origin and can be attributed to several genetic and environmental components. CVDs are the leading cause of mortality worldwide and they primarily damage the heart and the vascular system. Non-coding RNA (ncRNA) refers to functional RNA molecules, which have been transcribed into DNA but do not further get translated into proteins. Recent transcriptomic studies have identified the presence of thousands of ncRNA molecules across species. In humans, less than 2% of the total genome represents the protein-coding genes. While the role of many ncRNAs is yet to be ascertained, some long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have been associated with disease progression, serving as useful diagnostic and prognostic biomarkers. A plethora of data repositories specialized in ncRNAs have been developed over the years using publicly available high-throughput data from next-generation sequencing and other approaches, that cover various facets of ncRNA research like basic and functional annotation, expressional profile, structural and molecular changes, and interaction with other biomolecules. Here, we provide a compendium of the current ncRNA databases relevant to cardiovascular research.
心血管疾病（CVDs）起源于多因素，可归因于多种遗传和环境因素。心血管疾病是全球范围内主要的死亡原因，主要损害心脏和血管系统。非编码RNA（ncRNA）是指功能性RNA分子，它们已转录为DNA，但不会进一步翻译成蛋白质。最近的转录组学研究已经在多个物种中鉴定出数千种ncRNA分子的存在。在人类中，整个基因组中不到2%代表蛋白质编码基因。虽然许多ncRNA的作用尚未确定，但一些长链非编码RNA（lncRNA）和微小RNA（miRNA）已与疾病进展相关，可作为有用的诊断和预后生物标志物。多年来，利用来自下一代测序和其他方法的公开可用高通量数据，已经开发了大量专门针对ncRNA的数据存储库，这些数据存储库涵盖了ncRNA研究的各个方面，如基础和功能注释、表达谱、结构和分子变化以及与其他生物分子的相互作用。在这里，我们提供了与心血管研究相关的当前ncRNA数据库的概要。
