Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Exp Neurol. 2020 Dec;334:113457. doi: 10.1016/j.expneurol.2020.113457. Epub 2020 Sep 2.
Neonatal hypoxia-ischemia and resulting encephalopathies are of significant concern. Intrapartum asphyxia is a leading cause of neonatal death globally. Among surviving infants, there remains a high incidence of hypoxic-ischemic encephalopathy due to neonatal hypoxic-ischemic brain injury, manifesting as mild conditions including attention deficit hyperactivity disorder, and debilitating disorders such as cerebral palsy. Various animal models of neonatal hypoxic brain injury have been implemented to explore cellular and molecular mechanisms, assess the potential of novel therapeutic strategies, and characterize the functional and behavioural correlates of injury. Each of the animal models has individual advantages and limitations. The present review looks at several widely-used and alternative rodent models of neonatal hypoxia and hypoxia-ischemia; it highlights their strengths and limitations, and their potential for continued and improved use.
新生儿缺氧缺血和由此导致的脑病是一个严重的问题。产时窒息是全球新生儿死亡的主要原因。在幸存的婴儿中，由于新生儿缺氧缺血性脑损伤，仍有很高的发病率出现缺氧缺血性脑病，表现为轻度疾病，包括注意缺陷多动障碍，以及脑瘫等致残性疾病。已经实施了各种新生儿缺氧性脑损伤的动物模型，以探索细胞和分子机制、评估新的治疗策略的潜力，并描述损伤的功能和行为相关性。每种动物模型都有其自身的优点和局限性。本综述着眼于几种广泛使用和替代的新生鼠缺氧和缺氧缺血模型；它强调了它们的优势和局限性，以及它们持续和改进使用的潜力。
