D'Souza Karan, Birnie Blake W, Garraway Naisan
Division of General Surgery, Department of Surgery, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada; Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Int J Surg Case Rep. 2020;74:209-213. doi: 10.1016/j.ijscr.2020.08.037. Epub 2020 Aug 29.
Intestinal involvement of schistosomiasis uncommonly involves the formation of non-obstructive polypoid lesions; however, obstructing fibrotic stenoses and strictures secondary to chronic infection are extremely rare with only nine reported cases in the literature.
An 85-year-old Southeast Asian female originating from the Philippines presents with a one-day history of obstructive symptoms in the setting of chronic constipation over the past four months. Subsequent CT imaging and colonoscopy biopsy revealed a nodular cecal mural wall thickening with chronic inflammation and a single Schistosoma egg. Despite treatment with praziquantel, and medical optimization the patient did not improve. Additionally, a malignancy as the underlying cause of obstruction could not be ruled out as such, she had a right hemicolectomy. Final pathology confirmed the diagnosis of intestinal submucosal schistosomiasis causing fibrotic stenosis.
Obstructing lesions including fibrotic stenoses secondary to Schistosomiasis infection can be managed safely with medical co-morbidity optimization when possible, treatment with Praziquantel and surgical resection of the involved area of colon. Given the risk of malignancy and the inability to clinically distinguish between infectious and neoplastic processes, surgical management is recommended.
血吸虫病累及肠道时,形成非阻塞性息肉样病变的情况并不常见;然而,慢性感染继发的阻塞性纤维性狭窄极为罕见,文献中仅报道过9例。
一名85岁的东南亚女性,来自菲律宾,在过去四个月慢性便秘的情况下,出现了一天的阻塞性症状。随后的CT成像和结肠镜活检显示,盲肠壁结节状增厚,伴有慢性炎症和一个血吸虫卵。尽管使用吡喹酮进行了治疗,并进行了医疗优化,但患者病情并未改善。此外,由于不能排除恶性肿瘤是阻塞的潜在原因,因此她接受了右半结肠切除术。最终病理证实诊断为肠道黏膜下血吸虫病导致纤维性狭窄。
对于包括血吸虫病感染继发的纤维性狭窄在内的阻塞性病变,在可能的情况下,通过优化合并症、使用吡喹酮治疗以及手术切除结肠受累区域,可以安全地进行处理。鉴于存在恶性肿瘤的风险,且无法在临床上区分感染性和肿瘤性病变,建议采用手术治疗。