一名患有肠道血吸虫病患者的结直肠癌：坦桑尼亚乞力马扎罗基督教医疗中心北区的病例报告
Colorectal cancer in a patient with intestinal schistosomiasis: a case report from Kilimanjaro Christian Medical Center Northern Zone Tanzania.
作者信息
Herman Ayesiga M, Kishe Alfred, Babu Heri, Shilanaiman Hilary, Tarmohamed Murad, Lodhia Jay, Amsi Patrick, Pyuza Jeremia, Mremi Alex, Mwasamwaja Amos, Nyindo Mramba, Chilonga Kondo, Msuya David
机构信息
Department of General Surgery, Kilimanjaro Christian Medical Centre, P.O Box 3010, Moshi, Tanzania.
Department of Endoscopy, Kilimanjaro Christian Medical Center, P. O Box 3010, Moshi, Tanzania.
出版信息
World J Surg Oncol. 2017 Aug 2;15(1):146. doi: 10.1186/s12957-017-1217-1.
BACKGROUND
Colorectal cancer associated with chronic intestinal schistosomiasis has been linked with the chronic inflammation as a result of schistosomal ova deposition in the submucosal layer of the intestine. Among all species Schistosoma japonicum has been more linked to development of colorectal cancer as compared to Schistosoma mansoni due to absence of population-based studies to support the association. Despite the weak evidence, some cases have been reported associating S. mansoni with development of colorectal cancer.
CASE PRESENTATION
We report a patient who presented to us as a case of intestinal obstruction and found to have a constrictive lesion at the sigmoid colon at laparotomy, then later found to have colorectal cancer with deposited S. mansoni ova at histology.
CONCLUSION
Given the known late complications of schistosomiasis, and as S. mansoni is endemic in some parts of Tanzania, epidemiological studies are recommended to shed more light on its association with colorectal cancer.
背景
与慢性肠道血吸虫病相关的结直肠癌与血吸虫卵沉积于肠黏膜下层导致的慢性炎症有关。在所有血吸虫种类中，由于缺乏基于人群的研究来支持这种关联，与曼氏血吸虫相比，日本血吸虫与结直肠癌的发生联系更为紧密。尽管证据不足，但已有一些病例报告将曼氏血吸虫与结直肠癌的发生相关联。
病例报告
我们报告一名患者，该患者因肠梗阻前来就诊，剖腹手术时发现乙状结肠有一狭窄性病变，随后组织学检查发现患有结直肠癌且有曼氏血吸虫卵沉积。
结论
鉴于已知的血吸虫病晚期并发症，且曼氏血吸虫在坦桑尼亚的某些地区为地方病，建议开展流行病学研究以进一步阐明其与结直肠癌的关联。
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