Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph Stelzmann Strasse 26, 50931 Cologne, Germany.
Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph Stelzmann Strasse 26, 50931 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert Koch Strasse 21, 50931 Cologne, Germany.
Curr Opin Cell Biol. 2020 Dec;67:46-55. doi: 10.1016/j.ceb.2020.08.005. Epub 2020 Sep 2.
The proteostasis network adjusts protein composition and maintains protein integrity, which are essential processes for cell function and viability. Current efforts, given their intrinsic characteristics, regenerative potential and fundamental biological functions, have been directed to define proteostasis of stem cells. These insights demonstrate that embryonic stem cells and induced pluripotent stem cells exhibit an endogenous proteostasis network that not only modulates their pluripotency and differentiation but also provides a striking ability to suppress aggregation of disease-related proteins. Moreover, recent findings establish a central role of enhanced proteostasis to prevent the aging of somatic stem cells in adult organisms. Notably, proteostasis is also required for the biological purpose of adult germline stem cells, that is to be passed from one generation to the next. Beyond these links between proteostasis and stem cell function, we also discuss the implications of these findings for disease, aging, and reproduction.
蛋白质稳态网络调节蛋白质组成并维持蛋白质的完整性，这是细胞功能和活力的必要过程。鉴于其内在特性、再生潜力和基本生物学功能，目前的研究方向是定义干细胞的蛋白质稳态。这些研究结果表明，胚胎干细胞和诱导多能干细胞表现出一种内源性蛋白质稳态网络，不仅调节它们的多能性和分化，而且还提供了一种显著的能力来抑制与疾病相关的蛋白质聚集。此外，最近的研究结果确立了增强蛋白质稳态在预防成年生物体中体干细胞衰老中的核心作用。值得注意的是，蛋白质稳态对于生殖细胞干细胞的生物学目的也是必需的，即从一代传递到下一代。除了蛋白质稳态与干细胞功能之间的这些联系之外，我们还讨论了这些发现对疾病、衰老和生殖的影响。
