Zhang Dingkun, Deng Xuan, Li Mengqi, Qiu Min, Zhang Yifan, Li Gefei, Jiang Yurou, Tan Peng, Fan Sanhu, Zheng Youde, Lin Junzhi, Han Li, Huang Haozhou
State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of TCM, Chengdu, 611137, China.
Pharmacy Department, Sichuan Nursing Vocational College, Chengdu, 610100, China.
Chin Med. 2023 Oct 1;18(1):127. doi: 10.1186/s13020-023-00835-4.
Polyphenols are the main component of Phyllanthus emblica (PE). However, polyphenols are so easy to transform that it is unknown that how drying methods driven by heating affect the anti-fatigue effect of PE. This manuscript investigated the effects of five drying methods on the chemical composition transformation and anti-fatigue of PE, and discussed the action mechanism. The results suggested that the anti-fatigue effect of PE with hot-air-dried at 100 °C was the best, which was as 1.63 times as that with freeze-drying. Ellagic acid (EA) may be a key component of PE in anti-fatigue, and its mechanism of action may be related to regulating intestinal microbiota, protecting mitochondria, and regulating energy metabolism. This study first revealed the thermal transformation of polyphenols in PE, found the most effective strategy for enhancing the anti-fatigue function, and explores its action mechanism.
多酚是余甘子（PE）的主要成分。然而，多酚很容易发生转化，因此加热驱动的干燥方法如何影响余甘子的抗疲劳效果尚不清楚。本研究调查了五种干燥方法对余甘子化学成分转化及抗疲劳作用的影响，并探讨了其作用机制。结果表明，100℃热风干燥的余甘子抗疲劳效果最佳，是冷冻干燥余甘子的1.63倍。鞣花酸（EA）可能是余甘子抗疲劳的关键成分，其作用机制可能与调节肠道微生物群、保护线粒体和调节能量代谢有关。本研究首次揭示了余甘子中多酚的热转化，找到了增强抗疲劳功能的最有效策略，并探索了其作用机制。
