Evrensel Alper, Ünsalver Barış Önen, Özşahin Aytekin
Department of Electroneurophysiology, Üsküdar University Faculty of Health Sciences, İstanbul, Turkey.
Department of Psychiatry, Gülhane Military Medical Academy, Ankara, Turkey.
Noro Psikiyatr Ars. 2016 Jun;53(2):120-125. doi: 10.5152/npa.2015.9895. Epub 2016 Jun 1.
Aggression is one of the leading clinical characteristics of antisocial personality disorder (APD). Studies aiming to clarify and control the biological basis of aggression are ongoing. Thyroid hormones have been indicated to play a role in the development of aggression. The aim of this study was to examine the level of aggression and serum thyroid hormone in a sample of APD and to make contributions to this field with the current findings.
The sample consisted of 96 subjects with a diagnosis of APD and 97 subjects as a control group. Structured Clinical Interview for DSM-IV Axis (SCID) 1 and 2 were used for the diagnosis, and the Buss-Perry Aggression Questionnaire was administered. Based on criminal patterns, the APD group was then divided into two subgroups: "criminal" and "noncriminal" APD groups. The day after the interview, after one night of fasting, blood was collected from the subjects between 7:00 a.m. and 9:00 a.m.. Thyroid function tests and other biochemical analyses related to the confounding variables were also administered. The study group and the control group were compared in terms of their aggression scores and thyroid hormone levels.
The mean score of free T3 level in the criminal APD group was found to be significantly higher than that in the noncriminal APD group. APD subjects with higher free T3 levels also had higher aggression scores. In the noncriminal APD group, as serum free T3 and T4 levels increased, there was also an increment in the aggression scores. However, in the criminal APD group, there was no significant correlation between thyroid hormone levels and aggression.
The findings of this study indicated that criminal and noncriminal APD groups actually show different properties.
攻击性是反社会人格障碍（APD）的主要临床特征之一。旨在阐明和控制攻击性生物学基础的研究正在进行中。甲状腺激素已被表明在攻击性的发展中起作用。本研究的目的是检测一组反社会人格障碍患者的攻击性水平和血清甲状腺激素水平，并通过当前的研究结果为该领域做出贡献。
样本包括96名被诊断为反社会人格障碍的受试者和97名作为对照组的受试者。使用《精神疾病诊断与统计手册》第四版轴I和轴II的结构化临床访谈（SCID）进行诊断，并发放布斯-佩里攻击性问卷。然后根据犯罪模式，将反社会人格障碍组分为两个亚组：“犯罪型”和“非犯罪型”反社会人格障碍组。访谈后的第二天，在禁食一夜后，于上午7:00至9:00之间采集受试者的血液。还进行了甲状腺功能测试以及与混杂变量相关的其他生化分析。比较了研究组和对照组的攻击性得分和甲状腺激素水平。
发现犯罪型反社会人格障碍组的游离T3水平平均得分显著高于非犯罪型反社会人格障碍组。游离T3水平较高的反社会人格障碍受试者的攻击性得分也较高。在非犯罪型反社会人格障碍组中，随着血清游离T3和T4水平的升高，攻击性得分也有所增加。然而，在犯罪型反社会人格障碍组中，甲状腺激素水平与攻击性之间没有显著相关性。
本研究结果表明，犯罪型和非犯罪型反社会人格障碍组实际上表现出不同的特性。
