检测胸腔液中的肺炎链球菌抗原：一种基于免疫荧光的侧向流检测法在诊断肺炎球菌性肺炎中的应用价值。
Detection of Streptococcus pneumoniae antigen in pleural fluid: usefulness of an immunofluorescence-based lateral flow assay for the diagnosis of pneumococcal pneumonia.
机构信息
Microbiology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
出版信息
Diagn Microbiol Infect Dis. 2020 Dec;98(4):115162. doi: 10.1016/j.diagmicrobio.2020.115162. Epub 2020 Aug 5.
The performance of an immunofluorescence-based Streptococcus pneumoniae antigen detection test in pleural fluid (IF-PF) was evaluated. For proven and possible pneumococcal pneumonias global sensitivity and specificity were 92.6 (95 CI 76.6-97.9) and 80 (95 CI 62.7-90.5), respectively, with no significant differences between children and adults. Global diagnostic accuracy of IF-PF was 86% (74.2-93.7), and a substantial k index of concordance with culture/RT-PCR of 0.716 (0.535-0.896). IF-PF might be useful as a rapid complementary test for the etiologic diagnosis of pneumococcal pneumonia.
评估了一种基于免疫荧光的肺炎链球菌抗原检测试验（IF-PF）在胸腔积液中的表现。对于确诊和可能的肺炎球菌肺炎，全球敏感性和特异性分别为 92.6（95%CI76.6-97.9）和 80（95%CI62.7-90.5），儿童和成人之间无显著差异。IF-PF 的全球诊断准确性为 86%（74.2-93.7），与培养/RT-PCR 的一致性kappa 指数为 0.716（0.535-0.896）。IF-PF 可能是一种有用的快速辅助检测方法，用于肺炎球菌肺炎的病因诊断。
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