Stroke Center, Department of Neurology, First Hospital of Jilin University, Changchun, China.
Neuroscience Center, Department of Neurology, First Hospital of Jilin University, Changchun, China.
Eur J Neurol. 2021 Jan;28(1):161-171. doi: 10.1111/ene.14513. Epub 2020 Oct 5.
The burden of cervical arterial atherosclerosis, which is an important risk factor of stroke, is huge in China. The visceral adiposity index (VAI) is a convenient index that is related to a series of metabolic abnormalities and a variety of diseases, including cerebrovascular diseases. This study aimed to explore the relationship between VAI and cervical arterial atherosclerosis.
This cross-sectional study used the multistage stratified random cluster sampling method to acquire a representative sample of residents aged ≥40 in the general population of northeast China. All participants completed a detailed questionnaire and provided blood samples. Cervical vascular ultrasound was performed by experienced ultrasound doctors. VAI was calculated by a well-established formula and analyzed by quartiles (Q1-Q4).
A total of 3688 people aged ≥40 years who underwent cervical arterial ultrasound were finally included, amongst whom 3.2% had increased intima-media thickness (IMT), 48.6% had carotid plaque and 4.0% had cervical artery stenosis (CAS). After adjusting for several parameters, little statistical significance was found between VAI and increased IMT; compared with the VAI-Q1 group, the VAI-Q2, VAI-Q3 and VAI-Q4 groups were more likely to have CAS [odds ratio (OR) 2.01, 95% confidence interval (CI) 1.17-3.43; OR 1.82, 95% CI 1.05-3.15; OR 1.79, 95% CI 1.03-3.12] and the VAI-Q3 and VAI-Q4 groups were at greater risk of carotid plaque (OR 1.30, 95% CI 1.05-1.62; OR 1.34, 95% CI 1.07-1.67).
The VAI was related to carotid plaque and CAS in the general population that is older than 40 years.
在中国，颈动脉硬化这一重要的卒中危险因素的负担巨大。内脏脂肪指数（VAI）是一个方便的指标，与一系列代谢异常和多种疾病有关，包括脑血管疾病。本研究旨在探讨 VAI 与颈动脉硬化的关系。
本横断面研究采用多阶段分层随机聚类抽样方法，获取中国东北地区一般人群中≥40 岁居民的代表性样本。所有参与者完成详细的问卷调查并提供血液样本。由经验丰富的超声医生进行颈血管超声检查。通过一个成熟的公式计算 VAI，并按四分位（Q1-Q4）进行分析。
共纳入 3688 名年龄≥40 岁并接受颈动脉硬化超声检查的人群，其中 3.2%的人存在内膜中层厚度增加（IMT），48.6%的人有颈动脉斑块，4.0%的人有颈动脉硬化狭窄（CAS）。在校正了几个参数后，VAI 与 IMT 增加之间几乎没有统计学意义；与 VAI-Q1 组相比，VAI-Q2、VAI-Q3 和 VAI-Q4 组更有可能发生 CAS[比值比（OR）2.01，95%置信区间（CI）1.17-3.43；OR 1.82，95%CI 1.05-3.15；OR 1.79，95%CI 1.03-3.12]，VAI-Q3 和 VAI-Q4 组发生颈动脉斑块的风险更高（OR 1.30，95%CI 1.05-1.62；OR 1.34，95%CI 1.07-1.67）。
VAI 与 40 岁以上人群的颈动脉斑块和 CAS 有关。
