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多囊卵巢综合征母亲所生胎儿的超声肛门生殖距离更长。

Foetal Sonographic Anogenital Distance Is Longer in Polycystic Ovary Syndrome Mothers.

作者信息

Perlman Sharon, Toledano Yoel, Kivilevitch Zvi, Halevy Nufar, Rubin Elena, Gilboa Yinon

机构信息

The Helen Schneider Women's Hospital, Rabin Medical Centre, Ultrasound Unit, Zeev Jabotinsky Rd 39, Petah Tikva 49100, Israel.

Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.

出版信息

J Clin Med. 2020 Sep 4;9(9):2863. doi: 10.3390/jcm9092863.

DOI:10.3390/jcm9092863
PMID:32899698
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7563834/
Abstract

Anogenital distance (AGD) is a biomarker for the prenatal hormonal environment. Androgen excess is a key element in polycystic ovary syndrome (PCOS). The aim of this study was to assess the sonographic foetal AGD in a population of PCOS mothers in comparison to the general population. Foetal AGD was measured prospectively by 2D ultrasound in PCOS mothers and compared to prenatal AGD nomograms. The results were interpreted regarding maternal and foetal characteristics. The mean sonographic foetal AGD centile measurement in PCOS mothers was significantly longer in comparison to the general population (86.04% ± 18.22; < 0.001). Estimated foetal weight and birthweight were appropriate for gestational age and did not correlate with AGD. Sonographic foetal AGD was significantly longer in PCOS diabetic mothers and in those who conceived following assisted reproduction treatments when compared to the general population ( < 0.001). Our results support the role of AGD as a biomarker of the prenatal hormonal environment and provide evidence for the hyperandrogenic effect in PCOS pregnancies on foetal androgenic status and genitalia development.

摘要

肛殖距（AGD）是产前激素环境的生物标志物。雄激素过多是多囊卵巢综合征（PCOS）的关键因素。本研究的目的是评估多囊卵巢综合征母亲群体中胎儿超声测量的AGD，并与普通人群进行比较。通过二维超声前瞻性测量多囊卵巢综合征母亲的胎儿AGD，并与产前AGD列线图进行比较。根据母亲和胎儿的特征对结果进行解读。与普通人群相比，多囊卵巢综合征母亲中胎儿超声测量的AGD百分位数均值显著更长（86.04%±18.22；<0.001）。估计胎儿体重和出生体重与孕周相符，且与AGD无关。与普通人群相比，多囊卵巢综合征糖尿病母亲以及接受辅助生殖治疗后受孕的母亲中，胎儿超声测量的AGD显著更长（<0.001）。我们的结果支持AGD作为产前激素环境生物标志物的作用，并为多囊卵巢综合征妊娠中高雄激素对胎儿雄激素状态和生殖器发育的影响提供了证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e9/7563834/91dfd81e52ad/jcm-09-02863-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e9/7563834/826ad50f0894/jcm-09-02863-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e9/7563834/ba3724bba3e3/jcm-09-02863-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e9/7563834/9a8524de5fc5/jcm-09-02863-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e9/7563834/91dfd81e52ad/jcm-09-02863-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e9/7563834/826ad50f0894/jcm-09-02863-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e9/7563834/ba3724bba3e3/jcm-09-02863-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e9/7563834/9a8524de5fc5/jcm-09-02863-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e9/7563834/91dfd81e52ad/jcm-09-02863-g004.jpg

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Transl Psychiatry. 2018 Aug 1;8(1):136. doi: 10.1038/s41398-018-0186-7.
3
Obesity as disruptor of the female fertility.肥胖对女性生育能力的破坏。
Pathophysiology of polycystic ovary syndrome revisited: Current understanding and perspectives regarding future research.
多囊卵巢综合征的病理生理学再探讨：关于未来研究的当前认识与展望
Reprod Med Biol. 2022 Oct 8;21(1):e12487. doi: 10.1002/rmb2.12487. eCollection 2022 Jan-Dec.
4
Developmental Programming of Fertility in Cattle-Is It a Cause for Concern?牛生育力的发育编程——这值得关注吗？
Animals (Basel). 2022 Oct 3;12(19):2654. doi: 10.3390/ani12192654.
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Variation among human populations in endometriosis and PCOS A test of the inverse comorbidity model.子宫内膜异位症和多囊卵巢综合征在人群中的差异：反向共病模型的检验
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