Dietetic Department, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK.
Liverpool Clinical Trials Centre, University of Liverpool, Brownlow Hill, Liverpool L69 3GL, UK.
Nutrients. 2020 Sep 4;12(9):2704. doi: 10.3390/nu12092704.
Protein is the most satiating macronutrient, increasing secretion of gastrointestinal hormones and diet induced thermogenesis. In phenylketonuria (PKU), natural protein is restricted with approximately 80% of intake supplied by a synthetic protein source, which may alter satiety response. Casein glycomacropeptide (CGMP-AA), a carbohydrate containing peptide and alternative protein substitute to amino acids (AA), may enhance satiety mediated by its bioactive properties.
In a three-year longitudinal; prospective study, the effect of AA and two different amounts of CGMP-AA (CGMP-AA only (CGMP100) and a combination of CGMP-AA and AA (CGMP50) on satiety, weight and body mass index (BMI) were compared.
48 children with PKU completed the study. Median ages of children were: CGMP100; ( = 13), 9.2 years; CGMP50; ( = 16), 7.3 years; and AA ( = 19), 11.1 years. Semi-quantitative dietary assessments and anthropometry (weight, height and BMI) were measured every three months.
The macronutrient contribution to total energy intake from protein, carbohydrate and fat was similar across the groups. Adjusting for age and gender, no differences in energy intake, weight, BMI, incidence of overweight or obesity was apparent between the groups.
In this three-year longitudinal study, there was no indication to support a relationship between CGMP and satiety, as evidenced by decreased energy intake, thereby preventing overweight or obesity. Satiety is a complex multi-system process that is not fully understood.
在一项为期三年的前瞻性纵向研究中，比较了氨基酸（AA）和两种不同量的酪蛋白糖巨肽（CGMP-AA）（仅 CGMP-AA（CGMP100）和 CGMP-AA 与 AA 的组合（CGMP50）对饱腹感、体重和体重指数（BMI）的影响。
48 名苯丙酮尿症（PKU）儿童完成了这项研究。儿童的中位数年龄为：CGMP100（n = 13），9.2 岁；CGMP50（n = 16），7.3 岁；AA（n = 19），11.1 岁。每三个月进行一次半定量膳食评估和人体测量（体重、身高和 BMI）。
蛋白质、碳水化合物和脂肪在总能量摄入中的宏量营养素贡献在各组之间相似。调整年龄和性别后，各组之间的能量摄入、体重、BMI、超重或肥胖的发生率没有差异。
在这项为期三年的纵向研究中，没有证据表明 CGMP 与饱腹感之间存在关系，因为能量摄入没有减少，从而防止了超重或肥胖。饱腹感是一个复杂的多系统过程，尚未完全理解。
