Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam UMC, Location University of Amsterdam, Amsterdam, The Netherlands.
Cancer Center Amsterdam, Cancer Biology, Amsterdam, The Netherlands.
EMBO Mol Med. 2023 Mar 8;15(3):e15914. doi: 10.15252/emmm.202215914. Epub 2023 Jan 26.
Peritoneal metastases are a common form of tumor cell dissemination in gastrointestinal malignancies. Peritoneal metastatic disease (PMD) is associated with severe morbidity and resistance to currently employed therapies. Given the distinct route of dissemination compared with distant organ metastases, and the unique microenvironment of the peritoneal cavity, specific tumor cell characteristics are needed for the development of PMD. In this review, we provide an overview of the known histopathological, genomic, and transcriptomic features of PMD. We find that cancers representing the mesenchymal subtype are strongly associated with PMD in various malignancies. Furthermore, we discuss the peritoneal niche in which the metastatic cancer cells reside, including the critical role of the peritoneal immune system. Altogether, we show that PMD should be regarded as a distinct disease entity, that requires tailored treatment strategies.
腹膜转移是胃肠道恶性肿瘤中肿瘤细胞播散的一种常见形式。腹膜转移疾病（PMD）与严重的发病率和对目前使用的治疗方法的耐药性有关。鉴于与远处器官转移相比，PMD 具有独特的播散途径和腹膜腔的独特微环境，因此需要特定的肿瘤细胞特征来发展 PMD。在这篇综述中，我们概述了 PMD 的已知组织病理学、基因组和转录组特征。我们发现，代表间充质亚型的癌症与各种恶性肿瘤中的 PMD 强烈相关。此外，我们还讨论了转移性癌细胞所在的腹膜龛，包括腹膜免疫系统的关键作用。总的来说，我们表明 PMD 应该被视为一种独特的疾病实体，需要量身定制的治疗策略。
