Xiao Lihua, Tian Ying, Wu Juanying, Li Na, Zhang Caiping, Chen Wuzhe, Long Shiyin
Clin Lab. 2020 Sep 1;66(9). doi: 10.7754/Clin.Lab.2020.191247.
Metabolic syndrome (MS) is characterized by a constellation of metabolic disorders. Hyperglycemia and dyslipidemia are the major risk factors of MS. Here we performed a study to explore the association between glycated hemoglobin A1c (HbA1c) and high-density lipoprotein (HDL) subclasses in patients with MS.
We included 101 MS patients and 77 healthy subjects in this study. Blood tests were executed to assess the blood glucose and lipid indicators, including HbA1c, fasting plasma glucose (FPG), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein B100 (apoB100), preβ1-HDL, HDL3b, apoB100/AI, apolipoprotein AI (apoAI), HDL2b and HDL2a. Multivariate linear regression was used to explore potential relationship between HDL subclasses and HbA1c.
Compared with control group, the levels of HbA1c, FPG, TG, TC, LDL-C, apoB100, preβ1-HDL, HDL3b, apoB100/AI and LDL-C/HDL-C were significantly increased in MS subjects (p < 0.01), while plasma concentrations of HDL-C, apoAI, HDL2b and HDL2a were significantly decreased in MS subjects (p < 0.01). With the increase of whole blood HbA1c levels in MS subjects, preβ1-HDL was elevated gradually, while HDL2a was decreased gradually.
Blood HbA1c level is associated with the changes in HDL subclass distribution in patients with MS.
代谢综合征（MS）的特征是一系列代谢紊乱。高血糖和血脂异常是MS的主要危险因素。在此，我们开展了一项研究，以探讨MS患者糖化血红蛋白A1c（HbA1c）与高密度脂蛋白（HDL）亚类之间的关联。
本研究纳入了101例MS患者和77名健康受试者。进行血液检测以评估血糖和血脂指标，包括HbA1c、空腹血糖（FPG）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白B100（apoB100）、前β1-HDL、HDL3b、apoB100/AI、载脂蛋白AI（apoAI）、HDL2b和HDL2a。采用多变量线性回归来探讨HDL亚类与HbA1c之间的潜在关系。
与对照组相比，MS患者的HbA1c、FPG、TG、TC、LDL-C、apoB100、前β1-HDL、HDL3b、apoB100/AI和LDL-C/HDL-C水平显著升高（p<0.01），而MS患者的HDL-C、apoAI、HDL2b和HDL2a血浆浓度显著降低（p<0.01）。随着MS患者全血HbA1c水平的升高，前β1-HDL逐渐升高，而HDL2a逐渐降低。
血液HbA1c水平与MS患者HDL亚类分布的变化有关。
