Department of Radiology, University of Cambridge, Cambridge, United Kingdom.
Department of Radiology, Addenbrooke's Hospital, Cambridge, United Kingdom.
Br J Radiol. 2021 Mar 1;94(1119):20200427. doi: 10.1259/bjr.20200427. Epub 2020 Sep 9.
To compare diffusion-weighted images (DWI) acquired using single-shot echo-planar imaging (ss-EPI) and multiplexed sensitivity encoding (MUSE) in breast cancer.
20 females with pathologically confirmed breast cancer (age 51 ± 12 years) were imaged with ss-EPI-DWI and MUSE-DWI. ADC, normalised ADC (nADC), blur and distortion metrics and qualitative image quality scores were compared. The Crété-Roffet and Mattes mutual information metrics were used to evaluate blurring and distortion, respectively. In a breast phantom, six permutations of MUSE-DWI with varying parallel acceleration factor and number of shots were compared. Differences in ADC and nADC were compared using the coefficient of variation in the phantom and a paired t-test in patients. Differences in blur, distortion and qualitative metrics were analysed using a Wilcoxon signed-rank test.
There was a low coefficient of variation (<2%) in ADC between ss-EPI-DWI and all MUSE-DWI permutations acquired using the phantom. 22 malignant and three benign lesions were identified in 20 patients. ADC values measured using MUSE were significantly lower compared to ss-EPI for malignant but not benign lesions ( < 0.001, = 0.21). nADC values were not significantly different ( = 0.62, = 0.28). Blurring and distortion improved with number of shots and acceleration factor, and significantly improved with MUSE in patients ( < 0.001, = 0.002). Qualitatively, image quality improved using MUSE.
MUSE improves the image quality of breast DWI compared to ss-EPI.
MUSE-DWI has superior image quality and reduced blurring and distortion compared to ss-EPI-DWI in breast cancer.
比较单次激发回波平面成像(ss-EPI)和多重敏感编码(MUSE)在乳腺癌中的扩散加权成像(DWI)。
对 20 名经病理证实患有乳腺癌的女性(年龄 51±12 岁)进行了 ss-EPI-DWI 和 MUSE-DWI 成像。比较 ADC、归一化 ADC(nADC)、模糊度和失真指标以及定性图像质量评分。使用 Crété-Roffet 和 Mattes 互信息度量分别评估模糊度和失真。在乳房仿体中,比较了 MUSE-DWI 的六种不同的并行加速因子和射击次数的排列。在仿体中使用变异系数比较 ADC 和 nADC 的差异,在患者中使用配对 t 检验比较 ADC 和 nADC 的差异。使用 Wilcoxon 符号秩检验分析模糊度、失真和定性指标的差异。
在使用仿体获得的所有 MUSE-DWI 排列中,ss-EPI-DWI 和 MUSE-DWI 的 ADC 之间的变异系数均较低(<2%)。在 20 名患者中,共发现 22 个恶性和 3 个良性病变。与良性病变相比,恶性病变使用 MUSE 测量的 ADC 值显著降低(<0.001,=0.21)。nADC 值无显著差异(=0.62,=0.28)。随着射击次数和加速因子的增加,模糊度和失真得到改善,并且在患者中使用 MUSE 显著改善(<0.001,=0.002)。定性上,使用 MUSE 提高了图像质量。
与 ss-EPI 相比,MUSE 提高了乳腺癌 DWI 的图像质量。
与 ss-EPI-DWI 相比,MUSE-DWI 在乳腺癌中具有更好的图像质量,并且模糊度和失真更小。