Kowalczyk Joanna, Kurach Łukasz, Boguszewska-Czubara Anna, Skalicka-Woźniak Krystyna, Kruk-Słomka Marta, Kurzepa Jacek, Wydrzynska-Kuźma Małgorzata, Biała Grażyna, Skiba Adrianna, Budzyńska Barbara
Chair and Department of Applied Pharmacy, Medical University of Lublin, Lublin, Poland.
Independent Laboratory of Behavioral Studies, Medical University of Lublin, Lublin, Poland.
Front Neurosci. 2020 Aug 6;14:730. doi: 10.3389/fnins.2020.00730. eCollection 2020.
Bergapten is a furanocoumarin naturally occurring in the family it is a well-known photosensitizing agent used in photochemotherapy. In this study, we investigated the influence of bergapten on cognitive function and mechanism underlying these effects in scopolamine-induced memory impairment in male Swiss mice. The passive avoidance test was used to evaluate the efficiency of memory acquisition and consolidation. The results demonstrated that both single and repeated administration of bergapten improved not only the acquisition but also consolidation of memory. The behavioral tests showed that bergapten prevented memory impairment induced by administration of scopolamine. Observed effects may result from the inhibition of acetylcholinesterase activity in the hippocampus and prefrontal cortex. Also, bergapten caused significant anti-oxidative effects. These new findings provide pharmacological and biochemical support for the development of the coumarin's potential in cognitive deficits.
补骨脂素是一种天然存在于该科植物中的呋喃香豆素，它是光化学疗法中一种著名的光敏剂。在本研究中，我们研究了补骨脂素对雄性瑞士小鼠东莨菪碱诱导的记忆损伤中认知功能的影响及其作用机制。采用被动回避试验评估记忆获取和巩固的效率。结果表明，补骨脂素单次和重复给药不仅改善了记忆的获取，还改善了记忆的巩固。行为测试表明，补骨脂素可预防东莨菪碱给药引起的记忆损伤。观察到的效果可能是由于海马体和前额叶皮质中乙酰胆碱酯酶活性受到抑制。此外，补骨脂素还具有显著的抗氧化作用。这些新发现为香豆素在认知缺陷方面的潜在应用开发提供了药理学和生物化学支持。
