白细胞介素1增强肿瘤坏死因子α/恶病质素对小鼠的致死效应。
Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice.
作者信息
Waage A, Espevik T
机构信息
Cell Research Laboratory, Institute of Cancer Research, University of Trondheim, Norway.
出版信息
J Exp Med. 1988 Jun 1;167(6):1987-92. doi: 10.1084/jem.167.6.1987.
Abstract
Human rIL-1 alpha and human rIL-1 beta were examined for their ability to potentiate the lethal and hypothermic effects of mouse rTNF-alpha in mice. The LD50 of rTNF-alpha was 1.5 micrograms/mouse, whereas the LD50 of rTNF-alpha was reduced to 0.4 micrograms/mouse and 0.5 micrograms/mouse when rTNF-alpha was administered in combination with a nonlethal dose of rIL-1 alpha or rIL-1 beta, respectively. A similar rTNF-alpha enhancing effect of the rIL-1 was observed on the temperature response. The results show that the rIL-1 markedly potentiate the effects of rTNF-alpha on lethality and temperature in mice, and support our suggestion that TNF-alpha and IL-1 may have synergistic lethal effect in human septic shock.
摘要
研究了人重组白细胞介素-1α（rIL-1α）和人重组白细胞介素-1β（rIL-1β）增强小鼠rTNF-α致死和降温作用的能力。rTNF-α的半数致死量（LD50）为1.5微克/只小鼠，而当rTNF-α分别与非致死剂量的rIL-1α或rIL-1β联合给药时，rTNF-α的LD50分别降至0.4微克/只小鼠和0.5微克/只小鼠。在温度反应方面也观察到了rIL-1对rTNF-α类似的增强作用。结果表明，rIL-1可显著增强rTNF-α对小鼠致死性和体温的影响，支持了我们提出的TNF-α和IL-1在人类脓毒症休克中可能具有协同致死作用的观点。
相似文献
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Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice.白细胞介素1增强肿瘤坏死因子α/恶病质素对小鼠的致死效应。
J Exp Med. 1988 Jun 1;167(6):1987-92. doi: 10.1084/jem.167.6.1987.
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Synergistic anti-proliferative activity of interleukin 1 and tumor necrosis factor.白细胞介素1与肿瘤坏死因子的协同抗增殖活性
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Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.重组肿瘤坏死因子在培养的人血管内皮细胞中诱导促凝血活性：特性及与白细胞介素-1作用的比较
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4533-7. doi: 10.1073/pnas.83.12.4533.
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Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.肿瘤坏死因子（恶病质素）是一种内源性热原，可诱导白细胞介素1的产生。
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