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锌螯合剂N,N,N',N'-四(2-吡啶甲基)乙二胺降低了对亚胺培南的耐药性。 （你提供的原文中“Reduces the Resistance of to Imipenem”这里少了个主语，我按照合理推测翻译了，你可检查下原文是否准确。）

Zinc Chelator N,N,N',N'-Tetrakis(2-Pyridylmethyl)Ethylenediamine Reduces the Resistance of to Imipenem.

作者信息

He Siyuan, Zou Yuzhen, Zhan Mengling, Guo Qi, Zhang Yongjie, Zhang Zhemin, Li Bing, Zhang Shaoyan, Chu Haiqing

机构信息

Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, People's Republic of China.

Tongji University School of Medicine, Shanghai 200092, People's Republic of China.

出版信息

Infect Drug Resist. 2020 Aug 18;13:2883-2890. doi: 10.2147/IDR.S267552. eCollection 2020.

DOI:10.2147/IDR.S267552
PMID:32903882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7445496/
Abstract

PURPOSE

Imipenem is one of the very few effective options for treating () infections; the development of imipenem resistance is a major health concern.

MATERIALS AND METHODS

The susceptibility of 194 clinical isolates to imipenem was determined. The ability of imipenem to synergize with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN), a zinc chelator and a metallo-β-lactamases (MBLs) inhibitor, to inhibit growth was also assessed.

RESULTS

exhibited an elevated resistance to imipenem (MIC = 16 mg/L, MIC = 64 mg/L). A combination of TPEN and imipenem synergized to inhibit the growth of 100% of imipenem-resistant and 79.2% of imipenem-resistance intermediate isolates; no synergy was observed treating imipenem-sensitive isolates. A remarkable decrease in the MIC (from 16 to 4 mg/L) and MIC (from 64 to 8 mg/L) of imipenem was observed when it was combined with TPEN; the portion of imipenem-resistant isolates also decreased (from 48.4% to 0%). Consistent with these results demonstrating synergy, a time-kill assay showed the addition of TPEN significantly improved the bactericidal activity of imipenem toward . Similarly, EDTA (a potent MBLs inhibitor) promoted the anti- activity of imipenem in a disk assay, corroborating the effect of TPEN and supporting the role of MBLs in imipenem resistance exhibited by some isolates.

CONCLUSION

These findings demonstrate that TPEN can reduce the resistance of to imipenem and suggest that the inhibition of MBLs activity is the underlying mechanism.

摘要

目的

亚胺培南是治疗（）感染极少数有效的选择之一；亚胺培南耐药性的产生是一个主要的健康问题。

材料与方法

测定了194株临床分离株对亚胺培南的敏感性。还评估了亚胺培南与锌螯合剂及金属β-内酰胺酶（MBLs）抑制剂N,N,N',N'-四（2-吡啶甲基）乙二胺（TPEN）协同抑制（）生长的能力。

结果

（）对亚胺培南表现出耐药性升高（MIC = 16 mg/L，MIC = 64 mg/L）。TPEN与亚胺培南联合使用可协同抑制100%的亚胺培南耐药菌株和79.2%的亚胺培南耐药中介菌株的生长；在治疗亚胺培南敏感菌株时未观察到协同作用。当亚胺培南与TPEN联合使用时，观察到其MIC（从16降至4 mg/L）和MIC（从64降至8 mg/L）显著降低；亚胺培南耐药菌株的比例也有所下降（从48.4%降至0%）。与这些显示协同作用的结果一致，时间杀菌试验表明添加TPEN显著提高了亚胺培南对（）的杀菌活性。同样，在纸片扩散试验中，EDTA（一种有效的MBLs抑制剂）促进了亚胺培南的抗菌活性，证实了TPEN的作用，并支持了MBLs在一些分离株所表现出的亚胺培南耐药性中的作用。

结论

这些发现表明TPEN可降低（）对亚胺培南的耐药性，并提示抑制MBLs活性是其潜在机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e719/7445496/4ea141e4964f/IDR-13-2883-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e719/7445496/7cf92058a8c6/IDR-13-2883-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e719/7445496/356d4b75b7e3/IDR-13-2883-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e719/7445496/75ef7ac4834f/IDR-13-2883-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e719/7445496/4ea141e4964f/IDR-13-2883-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e719/7445496/7cf92058a8c6/IDR-13-2883-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e719/7445496/356d4b75b7e3/IDR-13-2883-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e719/7445496/75ef7ac4834f/IDR-13-2883-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e719/7445496/4ea141e4964f/IDR-13-2883-g0004.jpg

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