Pellegrino-Coppola Damiano
AI Lab One, Wilhelmina van Pruisenweg 35, 2595 AN The Hague, The Netherlands.
Microb Cell. 2020 Jun 22;7(9):222-233. doi: 10.15698/mic2020.09.728.
Aging is an evolutionarily conserved process and is tightly connected to mitochondria. To uncover the aging molecular mechanisms related to mitochondria, different organisms have been extensively used as model systems. Among these, the budding yeast has been reported multiple times as a model of choice when studying cellular aging. In particular, yeast provides a quick and trustworthy system to identify shared aging genes and pathway patterns. In this viewpoint on aging and mitochondria, I will focus on the mitochondrial permeability transition pore (mPTP), which has been reported and proposed as a main player in cellular aging. I will make several parallelisms with yeast to highlight how this unicellular organism can be used as a guidance system to understand conserved cellular and molecular events in multicellular organisms such as humans. Overall, a thread connecting the preservation of mitochondrial functionality with the activity of the mPTP emerges in the regulation of cell survival and cell death, which in turn could potentially affect aging and aging-related diseases.
衰老 是一个进化上保守的过程，与线粒体紧密相连。为了揭示与线粒体相关的衰老分子机制，不同的生物体已被广泛用作模型系统。其中，芽殖酵母在研究细胞衰老时多次被报道为首选模型。特别是，酵母提供了一个快速且可靠的系统来识别共同的衰老基因和通路模式。在这篇关于衰老与线粒体的观点文章中，我将聚焦于线粒体通透性转换孔（mPTP），它已被报道并被认为是细胞衰老的主要参与者。我将把酵母与其他情况进行若干类比，以突出这种单细胞生物如何能够作为一个指导系统，来理解诸如人类等多细胞生物中保守的细胞和分子事件。总体而言，在细胞存活和细胞死亡的调控中，出现了一条将线粒体功能的维持与mPTP的活性联系起来的线索，这反过来可能会潜在地影响衰老及与衰老相关的疾病。
