Temmam Sarah, Barbarino Alix, Maso Djérène, Behillil Sylvie, Enouf Vincent, Huon Christèle, Jaraud Ambre, Chevallier Lucie, Backovic Marija, Pérot Philippe, Verwaerde Patrick, Tiret Laurent, van der Werf Sylvie, Eloit Marc
Institut Pasteur, Pathogen Discovery Laboratory, Paris, France.
Institut Pasteur, The OIE Collaborating Centre for Detection and Identification in Humans of Emerging Animal Pathogens, Paris, France.
One Health. 2020 Dec;10:100164. doi: 10.1016/j.onehlt.2020.100164. Epub 2020 Aug 29.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, in 2019, is responsible for the COVID-19 pandemic. It is now accepted that the wild fauna, probably bats, constitute the initial reservoir of the virus, but little is known about the role pets can play in the spread of the disease in human communities, knowing the ability of SARS-CoV-2 to infect some domestic animals. In this cross-sectional study, we tested the antibody response in a cluster of 21 domestic pets (9 cats and 12 dogs) living in close contact with their owners (belonging to a veterinary community of 20 students) in which two students tested positive for COVID-19 and several others ( = 11/18) consecutively showed clinical signs (fever, cough, anosmia, ) compatible with COVID-19 infection. Although a few pets presented many clinical signs indicative for a coronavirus infection, no antibodies against SARS-CoV-2 were detectable in their blood one month after the index case was reported, using an immunoprecipitation assay. These original data can serve a better evaluation of the host range of SARS-CoV-2 in natural environment exposure conditions.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）于2019年起源于中国武汉，是导致新冠疫情的病原体。目前已知野生动物（可能是蝙蝠）是该病毒的初始宿主，但鉴于SARS-CoV-2能够感染一些家畜，宠物在人类社区疾病传播中所起的作用却鲜为人知。在这项横断面研究中，我们检测了一组21只家养宠物（9只猫和12只狗）的抗体反应，这些宠物与它们的主人（属于一个由20名学生组成的兽医群体）密切接触，其中两名学生新冠检测呈阳性，另有几名学生（11/18）相继出现了与新冠感染相符的临床症状（发热、咳嗽、嗅觉丧失等）。尽管有几只宠物出现了许多表明冠状病毒感染的临床症状，但在首例病例报告一个月后，采用免疫沉淀试验在它们的血液中未检测到针对SARS-CoV-2的抗体。这些原始数据有助于更好地评估在自然环境暴露条件下SARS-CoV-2的宿主范围。
