Bacalbasa Nicolae, Balescu Irina, Diaconu Camelia, Savu Carmen, Savu Cornel, Neacsu Adrian, Belu Emil, Bratu Ovidiu, Cretoiu Dragos, Halmaciu Ioana, Iliescu Laura, Balalau Cristian, Filipescu Alexandru, Vilcu Mihaela, Brezean Iulian
Department of Obstetrics and Gynecology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Department of Visceral Surgery, Center of Excellence in Translational Medicine, 'Fundeni' Clinical Institute, 022328 Bucharest, Romania.
Exp Ther Med. 2020 Oct;20(4):3523-3527. doi: 10.3892/etm.2020.9095. Epub 2020 Aug 4.
Due to the wide introduction of screening tests, patients with neoplastic diseases of the uterine cervix trend to be diagnosed in early stages of the disease, and less invasive surgical procedures are needed in certain cases. In this respect, the technique of sentinel lymph node dissection has been widely implemented as part of the therapeutic strategy, indocyanine green (ICG) being one of the most reliable markers for sentinel lymph node detection. However, it seems that this agent is extremely useful in order to achieve better short-term and long-term results after cervical cancer surgery, due to its capacity to determine the uterine vascular perfusion in cases in which conservative treatment, such as trachelectomy, is performed, as well as to prevent and treat lower limb lymphedema. A literature review was conducted of the studies which focused on the role of ICG utility in cervical cancer patients besides sentinel lymph node detection, special focus was given to vascularization preservation and lower limb lymphedema prevention and treatment.
由于筛查试验的广泛应用，子宫颈肿瘤性疾病患者往往在疾病早期被诊断出来，某些情况下需要的手术侵入性较小。在这方面，前哨淋巴结清扫技术已作为治疗策略的一部分被广泛应用，吲哚菁绿（ICG）是前哨淋巴结检测最可靠的标志物之一。然而，由于其能够在进行诸如宫颈锥切术等保守治疗的情况下确定子宫血管灌注，以及预防和治疗下肢淋巴水肿，这种药物似乎对于在宫颈癌手术后取得更好的短期和长期效果极为有用。对除前哨淋巴结检测外重点关注ICG在宫颈癌患者中作用的研究进行了文献综述，特别关注了血管化保留以及下肢淋巴水肿的预防和治疗。
