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四例颅底凹陷综合征病例报告:临床表现、CT表现及治疗

Report of four cases of crowned dens syndrome: Clinical presentation, CT findings and treatment.

作者信息

Tang Jin, Li Junjie, Wu Congjun, Li Ying, Lu Qilin, Xie Wei, Zhang Tonghui, Li Xugui

机构信息

Department of Minimally Invasive Spinal Surgery, Hubei 672 Orthopaedics Hospital of Integrated Chinese and Western Medicine, Wuhan, Hubei 430079, P.R. China.

出版信息

Exp Ther Med. 2020 Oct;20(4):3853-3859. doi: 10.3892/etm.2020.9128. Epub 2020 Aug 21.

Abstract

The clinical manifestations of crowned dens syndrome (CDS) include acute neck pain and neck stiffness accompanied by restricted cervical range of motion. CDS is frequently misdiagnosed as meningitis, epidural abscess, rheumatoid arthritis, rheumatoid polymyalgia, giant cell arteritis, cervical spondylosis or metastatic bone tumor, and the incidence of CDS appears to be underestimated. The present study reported on four cases of CDS diagnosed by CT. They included one male and three females, aged from 67 to 78 years, and their major symptoms were acute neck pain and restricted cervical range of motion. Serum C-reactive protein levels and erythrocyte sedimentation rate were significantly increased in all cases. Cervical CT scan revealed calcified deposits surrounding the odontoid process in all cases. Non-steroidal anti-inflammatory drugs (NSAIDs) markedly reduced the levels of inflammatory indicators and rapidly relieved the symptoms. CT scan is considered the gold standard for CDS diagnosis, which may demonstrate calcification around the odontoid process. The patients' symptoms may be improved by treatment with NSAIDs.

摘要

颅底凹陷综合征(CDS)的临床表现包括急性颈部疼痛和颈部僵硬,并伴有颈椎活动范围受限。CDS常被误诊为脑膜炎、硬膜外脓肿、类风湿关节炎、风湿性多肌痛、巨细胞动脉炎、颈椎病或转移性骨肿瘤,且CDS的发病率似乎被低估了。本研究报告了4例经CT诊断的CDS病例。其中包括1名男性和3名女性,年龄在67至78岁之间,其主要症状为急性颈部疼痛和颈椎活动范围受限。所有病例的血清C反应蛋白水平和红细胞沉降率均显著升高。颈椎CT扫描显示所有病例齿状突周围有钙化沉积物。非甾体抗炎药(NSAIDs)可显著降低炎症指标水平并迅速缓解症状。CT扫描被认为是CDS诊断的金标准,其可显示齿状突周围的钙化。使用NSAIDs治疗可改善患者症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2fa/7465381/ff86a085ddaf/etm-20-04-3853-g00.jpg

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