Conteh Abdul Rahman, Huang Ruixue
Department of Occupational and Environmental Health, Xiangya School of Public Heath, Central South University, 932 Lushan S Rd, Yuelu District, Changsha 410078, China.
Toxicol Res (Camb). 2020 Aug 25;9(4):569-577. doi: 10.1093/toxres/tfaa065. eCollection 2020 Jul.
Increasing numerous diabetes annually is a great concern in public health globally. Gut microbiota recently has been suggested to be an emerging organ acting as a critical regulator in diabetes. Notably, gut microbiota is closely affected through an individual's nutrient intake and dietary pattern. Moreover, the metabolites of diets through gut microbiota are closely associated with the development of diabetes. Increasing evidence has established the association of different dietary pattern with alterations of the gut microbiota profile, in particular, the Asian diet and Western diet are typically as essential components linked to the interactions between gut microbiota and induction of obesity which is a significant risk factor for diabetes. In addition, some bacteria-related therapeutic methods including probiotics, dietary short-chain fatty acids immunotherapy, and gut microbiome transfer would be applied in the clinical prevention and control diabetes. Taken together, based on current published observations, the gut microbiota may serve as regulator or targets by the Asian diet and Western diet, contributing to the prevention or induction of diabetes eventually. In general, in the upcoming future, one of the emerging strategies for the prevention and control of diabetes may modulate gut microbiota through precise dietary strategies.
每年糖尿病患者数量的不断增加是全球公共卫生领域极为关注的问题。最近有研究表明，肠道微生物群是一个新兴器官，在糖尿病中起着关键调节作用。值得注意的是，肠道微生物群会受到个体营养摄入和饮食模式的密切影响。此外，饮食通过肠道微生物群产生的代谢产物与糖尿病的发展密切相关。越来越多的证据表明，不同的饮食模式与肠道微生物群谱的改变有关，特别是亚洲饮食和西方饮食通常是与肠道微生物群相互作用以及诱发肥胖相关的重要因素，而肥胖是糖尿病的一个重要危险因素。此外，一些与细菌相关的治疗方法，包括益生菌、饮食短链脂肪酸免疫疗法和肠道微生物群移植，将应用于糖尿病的临床预防和控制。综上所述，根据目前已发表的观察结果，肠道微生物群可能是亚洲饮食和西方饮食的调节因子或靶点，最终导致糖尿病的预防或诱发。总的来说，在未来，预防和控制糖尿病的新兴策略之一可能是通过精确的饮食策略调节肠道微生物群。
