Department of Life Sciences and Systems Biology, University of Turin, Via Quarello 15/a, 10135 Turin, Italy.
Int J Mol Sci. 2020 Sep 7;21(18):6540. doi: 10.3390/ijms21186540.
(E)-β-caryophyllene (BCP) is a natural sesquiterpene hydrocarbon present in hundreds of plant species. BCP possesses several important pharmacological activities, ranging from pain treatment to neurological and metabolic disorders. These are mainly due to its ability to interact with the cannabinoid receptor 2 (CB2) and the complete lack of interaction with the brain CB1. A systematic analysis of plant species with essential oils containing a BCP percentage > 10% provided almost 300 entries with species belonging to 51 families. The essential oils were found to be extracted from 13 plant parts and samples originated from 56 countries worldwide. Statistical analyses included the evaluation of variability in BCP% and yield% as well as the statistical linkage between families, plant parts and countries of origin by cluster analysis. Identified species were also grouped according to their presence in the Belfrit list. The survey evidences the importance of essential oil yield evaluation in support of the chemical analysis. The results provide a comprehensive picture of the species with the highest BCP and yield percentages.
(E)-β-石竹烯（BCP）是一种天然倍半萜烃，存在于数百种植物物种中。BCP 具有多种重要的药理活性，从疼痛治疗到神经和代谢紊乱。这主要是由于其与大麻素受体 2（CB2）相互作用的能力以及与大脑 CB1 完全没有相互作用。对含有 BCP 百分比>10%的精油的植物物种进行系统分析，提供了近 300 项条目，这些物种属于 51 个科。精油是从 13 种植物部位提取的，样本来自全球 56 个国家。统计分析包括评估 BCP%和产率%的变异性，以及通过聚类分析对科、植物部位和原产国之间的统计联系进行评估。还根据它们在 Belfrit 清单中的存在情况对鉴定出的物种进行了分组。该调查证明了评估精油产量以支持化学分析的重要性。结果提供了具有最高 BCP 和产率百分比的物种的综合图片。
