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3种化妆品对刺激性化学物质（辣椒素）引起的皮肤不适的舒缓效果的对照比较评估

Controlled comparison evaluation of the soothing effect of 3 cosmetic products on skin discomfort induced by an irritant chemical agent (capsaicin).

作者信息

Vitale Maria, López Ana, Truchuelo Maria Teresa, Nobile Vincenzo, Milani Massimo, Gómez-Sánchez María José

机构信息

Medical Affairs Department, Cantabria Labs, Madrid, Spain.

R&D Department, Cantabria Labs, Madrid, Spain.

出版信息

J Cosmet Dermatol. 2024 Dec;23(12):4057-4065. doi: 10.1111/jocd.16526. Epub 2024 Sep 5.

DOI:10.1111/jocd.16526
PMID:39234948
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11626353/
Abstract

BACKGROUND

Sensitive skin is a highly prevalent problem. The objective of the study was to assess whether the tested products are effective and safe in terms of improving the symptoms of sensitive skin.

METHODS

A clinical randomized split-face study was carried out on 24 healthy female subjects. Three cosmetic combinations were tested versus vehicle: product A (Solía Thermal Spring Water-TSW-from Cantabria, Spain + diatom algae-P. tricornutum-extract), product B (Solía TSW + diatom algae extract + Annona cherimola Fruit Extract) and product C (Solía TSW + diatom algae extract + Annona cherimola Fruit Extract + niacinamide). Prior to each application of the study Product (A, B, or C)/vehicle, 10% of aqueous solution of capsaicin to induce skin irritation was applied, mimicking the symptoms of sensitive skin. Stinging and burning sensations were evaluated at different time points.

RESULTS

All three tested products A, B, and C showed to act better in calming the symptoms induced by capsaicin when compared to the vehicle.

CONCLUSIONS

The tested products would be an interesting option for treating stinging and burning sensations in sensitive skin patients.

摘要

背景

敏感性皮肤是一个非常普遍的问题。本研究的目的是评估受试产品在改善敏感性皮肤症状方面是否有效和安全。

方法

对24名健康女性受试者进行了一项临床随机半脸研究。测试了三种化妆品组合与赋形剂的对比效果：产品A（来自西班牙坎塔布里亚的索利亚温泉水-TSW+硅藻-P. tricornutum-提取物）、产品B（索利亚TSW+硅藻提取物+番荔枝果提取物）和产品C（索利亚TSW+硅藻提取物+番荔枝果提取物+烟酰胺）。在每次涂抹研究产品（A、B或C）/赋形剂之前，涂抹10%的辣椒素水溶液以诱导皮肤刺激，模拟敏感性皮肤的症状。在不同时间点评估刺痛和灼烧感。

结果

与赋形剂相比，所有三种受试产品A、B和C在缓解辣椒素引起的症状方面表现更好。

结论

受试产品可能是治疗敏感性皮肤患者刺痛和灼烧感的一个有趣选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56c3/11626353/1aebf8632962/JOCD-23--g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56c3/11626353/13778b68ebb7/JOCD-23--g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56c3/11626353/946a8528083d/JOCD-23--g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56c3/11626353/1aebf8632962/JOCD-23--g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56c3/11626353/13778b68ebb7/JOCD-23--g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56c3/11626353/946a8528083d/JOCD-23--g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56c3/11626353/1aebf8632962/JOCD-23--g002.jpg

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