Dai Amy, Malmqvist Lasse, Rothenbuehler Simon P, Hamann Steffen
Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Glostrup, Denmark.
Department of Ophthalmology, University Hospital Basel, Basel, Switzerland.
Eur J Ophthalmol. 2021 Sep;31(5):2563-2570. doi: 10.1177/1120672120957591. Epub 2020 Sep 9.
To examine optic nerve head (ONH) anatomy in young adults with central retinal vein occlusion (CRVO), branch retinal vein occlusion (BRVO), central retinal artery occlusion (CRAO), branch retinal artery occlusion (BRAO) or nonarteritic anterior ischemic optic neuropathy (NA-AION) in order to look for associated, potentially predisposing anomalies.
Cross-sectional study including 54 patients (ages 16-50 years) diagnosed from 2009 to 2018 with CRVO, BRVO, CRAO, BRAO, or NA-AION. Using Optical Coherence Tomography the presence of optic disc drusen (ODD), prelaminar hyperreflective lines and peripapillary hyperreflective ovoid mass-like structures (PHOMS), and determination of scleral canal size, retinal nerve fiber layer thickness (RNFLT) and macular ganglion cell layer thickness (GCLT) was obtained. Data for retinal vascular occlusion patients were grouped and analyzed together.
ODD were found in 13% of all patients, 2% of retinal vascular occlusion patients and 67% of NA-AION patients ( < 0.0001). Prelaminar hyperreflective lines were found in 35% of all patients, 24% of retinal vascular occlusion patients and 89% of NA-AION patients ( = 0.0005). PHOMS were found in 20% of all patients, 13% of retinal vascular occlusion patients and 56% of NA-AION patients ( = 0.012). RNFLT was decreased in ODD patients compared to patients without ODD ( = 0.01). Scleral canal diameter and GCLT was not correlated with ODD, prelaminar hyperreflective lines or PHOMS.
ODD, prelaminar hyperreflective lines and PHOMS were more frequent in NA-AION patients compared to retinal vascular occlusion patients. The prevalence of ODD in retinal vascular occlusion patients was similar to the reported prevalence in the general population.
研究中心视网膜静脉阻塞（CRVO）、视网膜分支静脉阻塞（BRVO）、中心视网膜动脉阻塞（CRAO）、视网膜分支动脉阻塞（BRAO）或非动脉性前部缺血性视神经病变（NA-AION）的年轻成年人的视神经乳头（ONH）解剖结构，以寻找相关的、可能的易患异常。
横断面研究，纳入2009年至2018年诊断为CRVO、BRVO、CRAO、BRAO或NA-AION的54例患者（年龄16 - 50岁）。使用光学相干断层扫描，检测视盘小疣（ODD）、板层前高反射线和视乳头周围高反射卵形块状结构（PHOMS）的存在，并测定巩膜管大小、视网膜神经纤维层厚度（RNFLT）和黄斑神经节细胞层厚度（GCLT）。将视网膜血管阻塞患者的数据分组并一起分析。
在所有患者中，13%发现有ODD，视网膜血管阻塞患者中为2%，NA-AION患者中为67%（P < 0.0001）。在所有患者中，35%发现有板层前高反射线，视网膜血管阻塞患者中为24%，NA-AION患者中为89%（P = 0.0005）。在所有患者中，20%发现有PHOMS，视网膜血管阻塞患者中为13%，NA-AION患者中为56%（P = 0.012）。与无ODD的患者相比，ODD患者的RNFLT降低（P = 0.01）。巩膜管直径和GCLT与ODD、板层前高反射线或PHOMS无关。
与视网膜血管阻塞患者相比，NA-AION患者中ODD、板层前高反射线和PHOMS更为常见。视网膜血管阻塞患者中ODD的患病率与一般人群中报告的患病率相似。
