腰椎管狭窄症患者行显微镜下减压椎板切除术与经皮内镜减压椎板切除术的比较：系统评价与荟萃分析方案
Microscopic decompressive laminectomy versus percutaneous endoscopic decompressive laminectomy in patients with lumbar spinal stenosis: protocol for a systematic review and meta-analysis.
作者信息
Wang Rong, Li Xiuxia, Zhang Xiaogang, Qin Daping, Yang Guodong, Gao Guodong, Zhang Hua
机构信息
Department of Spine Surgery, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, Gansu, China.
Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, Gansu, China.
出版信息
BMJ Open. 2020 Sep 9;10(9):e037096. doi: 10.1136/bmjopen-2020-037096.
INTRODUCTION
Lumbar spinal stenosis (LSS) is a common lumbar degenerative disease in the elderly, usually requiring surgery if conservative treatment fails. Microscopic decompressive laminectomy (MDL) and percutaneous endoscopic decompressive laminectomy (PEDL) have been widely used to treat LSS. This study aims to provide a protocol for the evaluation and comparison of the efficacy, safety and applicability between MDL and PEDL.
METHODS AND ANALYSIS
We will search for randomised controlled trials (RCTs) comparing MDL and PEDL for treating LSS from inception to December 2019 in the following databases: PubMed, The Cochrane Library, Web of Science, Embase and China Biology Medicine. The quality of included studies will be assessed using the risk of bias tool recommended by the Cochrane Handbook 5.2.0. Subsequently, a meta-analysis will be performed using RevMan 5.3 software.
ETHICS AND DISSEMINATION
Given the nature of this study, no ethical approval will be required. The protocol will be disseminated via a peer-reviewed journal.
PROSPERO REGISTRATION NUMBER
CRD42020164765.
引言
腰椎管狭窄症（LSS）是老年人常见的腰椎退行性疾病，若保守治疗失败通常需要手术治疗。显微减压椎板切除术（MDL）和经皮内镜减压椎板切除术（PEDL）已广泛用于治疗LSS。本研究旨在提供一个评估和比较MDL与PEDL在疗效、安全性和适用性方面的方案。
方法与分析
我们将在以下数据库中检索从建库至2019年12月比较MDL和PEDL治疗LSS的随机对照试验（RCT）：PubMed、Cochrane图书馆、科学网、Embase和中国生物医学数据库。将使用Cochrane手册5.2.0推荐的偏倚风险工具评估纳入研究的质量。随后，将使用RevMan 5.3软件进行荟萃分析。
伦理与传播
鉴于本研究的性质，无需伦理批准。该方案将通过同行评审期刊进行传播。
PROSPERO注册号：CRD42020164765。
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