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来自酿酒酵母的一段189个核苷酸的可 dispensible（此处可能有误，推测为“可缺失的”，dispensable）小核仁RNA的序列及遗传分析

Sequence and genetic analysis of a dispensible 189 nucleotide snRNA from Saccharomyces cerevisiae.

作者信息

Thompson J R, Zagorski J, Woolford J L, Fournier M J

机构信息

Department of Biochemistry, University of Massachusetts, Amherst 01003.

出版信息

Nucleic Acids Res. 1988 Jun 24;16(12):5587-601. doi: 10.1093/nar/16.12.5587.

DOI:10.1093/nar/16.12.5587
PMID:3290853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC336786/
Abstract

The structure of a Saccharomyces cerevisiae gene that encodes a small nuclear RNA (snRNA) of 189 nucleotides is described. This gene, designated SNR189, is located 400 base pairs upstream of the CRY1 gene on yeast chromosome III. Gene replacement analysis revealed the SNR189 gene to be dispensable for growth under a variety of culture conditions. The snR189 sequence lacks homology with other sequenced yeast or metazoan snRNAs.

摘要

本文描述了酿酒酵母中一个编码189个核苷酸的小核RNA（snRNA）的基因结构。这个名为SNR189的基因位于酵母III号染色体上CRY1基因上游400个碱基对处。基因置换分析表明，在多种培养条件下，SNR189基因对于细胞生长并非必需。snR189序列与其他已测序的酵母或后生动物snRNA没有同源性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/401f/336786/952772ebc3ed/nar00155-0375-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/401f/336786/e5beac853b51/nar00155-0366-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/401f/336786/575bf92af34b/nar00155-0368-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/401f/336786/baefd00a8591/nar00155-0369-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/401f/336786/9671f9575eab/nar00155-0374-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/401f/336786/952772ebc3ed/nar00155-0375-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/401f/336786/e5beac853b51/nar00155-0366-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/401f/336786/575bf92af34b/nar00155-0368-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/401f/336786/baefd00a8591/nar00155-0369-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/401f/336786/9671f9575eab/nar00155-0374-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/401f/336786/952772ebc3ed/nar00155-0375-a.jpg

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Sequence and genetic analysis of a dispensible 189 nucleotide snRNA from Saccharomyces cerevisiae.来自酿酒酵母的一段189个核苷酸的可 dispensible（此处可能有误，推测为“可缺失的”，dispensable）小核仁RNA的序列及遗传分析
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引用本文的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
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The small nucleolar RNP protein NOP1 (fibrillarin) is required for pre-rRNA processing in yeast.小核仁核糖核蛋白NOP1（纤维原蛋白）是酵母前体核糖体RNA加工所必需的。
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Isolation and characterization of rabbit anti-m3 2,2,7G antibodies.兔抗-m3 2,2,7G抗体的分离与鉴定
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Sequences responsible for transcription termination on a gene segment in Saccharomyces cerevisiae.酿酒酵母基因片段上负责转录终止的序列。
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A comparison of yeast ribosomal protein gene DNA sequences.酵母核糖体蛋白基因DNA序列的比较
Nucleic Acids Res. 1984 Nov 26;12(22):8295-312. doi: 10.1093/nar/12.22.8295.
7
Molecular cloning and analysis of the CRY1 gene: a yeast ribosomal protein gene.CRY1基因的分子克隆与分析：一个酵母核糖体蛋白基因
Nucleic Acids Res. 1983 Jan 25;11(2):403-20. doi: 10.1093/nar/11.2.403.
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Transformation of intact yeast cells treated with alkali cations.经碱金属阳离子处理的完整酵母细胞的转化
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One-step gene disruption in yeast.酵母中的一步基因破坏
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