Aarestrup Paula F, Aarestrup Matheus F, Aarestrup Beatriz J V, Aarestrup Fernando M
Universidade Federal do Rio de Janeiro-UNIRIO, Rio de Janeiro, Brazil.
Instituto de Ensino Superior Tancredo Neves-IPTAN, São João Del Rei, Minas Gerais, Brazil.
Case Rep Otolaryngol. 2020 Aug 24;2020:6313176. doi: 10.1155/2020/6313176. eCollection 2020.
Selective IgA deficiency is the most common type of primary immunodeficiency, but there is not yet a specific effective treatment. The most prevalent clinical manifestations are infectious diseases of the respiratory system. We report herein the case of an 11-year-old female with selective IgA deficiency and recurring episodes of respiratory infections associated with rhinitis and asthma. We evaluated the efficacy of sublingual immunotherapy combined with inactivated whole-cell bacterial extract and Der p1-specific immunotherapy. After 18 months of clinical follow-up, we observed a significant reduction in the number of episodes of respiratory infections associated with control of atopic diseases. We also observed a 3-fold increase in serum IgA levels compared to treatment initiation. This case demonstrates the potential utility of the concurrent use of sublingual immunotherapy with inactivated whole-cell bacterial extract and Der p1 for successful control of allergy and infection in partial selective IgA deficiency.
选择性IgA缺乏症是最常见的原发性免疫缺陷类型，但目前尚无特异性有效治疗方法。最常见的临床表现是呼吸系统感染性疾病。我们在此报告一例11岁女性选择性IgA缺乏症患者，反复出现与鼻炎和哮喘相关的呼吸道感染发作。我们评估了舌下免疫疗法联合灭活全细胞细菌提取物和Der p1特异性免疫疗法的疗效。经过18个月的临床随访，我们观察到与特应性疾病得到控制相关的呼吸道感染发作次数显著减少。与治疗开始时相比，我们还观察到血清IgA水平增加了3倍。该病例证明了舌下免疫疗法与灭活全细胞细菌提取物和Der p1同时使用对于成功控制部分选择性IgA缺乏症中的过敏和感染具有潜在效用。
