Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Hokkaido, Japan.
Dig Endosc. 2021 Sep;33(6):903-911. doi: 10.1111/den.13825. Epub 2020 Oct 8.
The relevance of endoscopic monitoring of ulcerative colitis (UC) has been translated into the new concept of "mucosal healing (MH)" as the therapeutic goal to achieve because a large amount of scientific data have revealed the favorable prognostic value of a healed mucosa in determining the clinical outcome of UC. Recent interest in MH has skewed toward not only endoscopic remission but also histological improvement (so called histological MH). However, we should recognize that there have been no prospectively validated endoscopic scoring systems of UC activity in previous clinical trials. Artificial intelligence (AI)-assisted endoscopy has been developed for gastrointestinal cancer surveillance. Recently, several AI-assisted endoscopic systems have been developed for assessment of MH in UC. In the future, the development of a new endoscopic scoring system based on AI might standardize the definition of MH. Therefore, "The road to an exact definition of MH in the treatment of UC has begun only now".
溃疡性结肠炎(UC)内镜监测的相关性已转化为新的“黏膜愈合(MH)”治疗目标,因为大量科学数据揭示了愈合的黏膜在确定 UC 的临床结果方面具有良好的预后价值。最近,人们对 MH 的兴趣不仅转向了内镜缓解,也转向了组织学改善(所谓的组织学 MH)。然而,我们应该认识到,在以前的临床试验中,还没有针对 UC 活动的经过前瞻性验证的内镜评分系统。人工智能(AI)辅助内镜检查已开发用于胃肠道癌症监测。最近,已经开发了几种用于评估 UC 中 MH 的 AI 辅助内镜系统。在未来,基于 AI 的新型内镜评分系统的开发可能会使 MH 的定义标准化。因此,“UC 治疗中 MH 的确切定义之路才刚刚开始”。
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