Sezgin Burak, Kinci Mehmet F, Pirinççi Fatih, Camuzcuoğlu Aysun, Erel Özcan, Neşelioğlu Salim, Camuzcuoğlu Hakan
Department of Obstetrics and Gynecology, Faculty of Medicine, Muğla Sıtkı Koçman University, Muğla, Turkey.
Department of Obstetrics and Gynecology, Mugla Sitki Kocman University Training and Research Hospital, Muğla, Turkey.
J Obstet Gynaecol Res. 2020 Nov;46(11):2423-2429. doi: 10.1111/jog.14480. Epub 2020 Sep 9.
The evaluation of dynamic thiol-disulfide homeostasis among patients with the cancer of the uterine cervix.
The study was conducted in 62 cervical cancer patients and 61 healthy women who had been followed up in an obstetrics and gynecology clinic between September 2018 and April 2020. Serum disulfide, native thiol, total thiol, ischemia modified-albumin, total antioxidant and oxidant capacities, and oxidative stress index values were measured in all participants.
The mean plasma disulfide levels of the cervical cancer group was statistically significantly higher than that of the control group (25.79 ± 6.90 μmol/L, 22.31 ± 6.11 μmol/L, respectively) (P = 0.004). Plasma native thiol and total thiol levels were lower in cervical cancer patients (299.27 ± 99.05 μmol/L and 350.86 ± 102.72 μmol/L, respectively) compared to controls, but no statistically significant difference was observed (318.00 ± 93.75 μmol/L and 376.44 ± 98.51 μmol/L, respectively) (P = 0.284, P = 0.161). With respect to the ischemia modified-albumin level, no statistically significant difference was observed between two groups. There were statistically significant positive association between disulfide level and both the stage of cervical cancer (r = 0.278, P = 0.029) and total oxidant capacity level (r = 0.256, P = 0.046).
Dynamic thiol-disulfide homeostasis may participate in the pathophysiological mechanisms of cervical cancer and may be a potential biomarker for early identification of cervical cancer in future.
评估子宫颈癌患者动态硫醇 - 二硫键稳态。
本研究纳入了2018年9月至2020年4月期间在妇产科诊所随访的62例宫颈癌患者和61例健康女性。检测了所有参与者的血清二硫键、天然硫醇、总硫醇、缺血修饰白蛋白、总抗氧化能力和氧化能力以及氧化应激指数值。
宫颈癌组的平均血浆二硫键水平显著高于对照组（分别为25.79±6.90μmol/L和22.31±6.11μmol/L）（P = 0.004）。与对照组相比，宫颈癌患者的血浆天然硫醇和总硫醇水平较低（分别为299.27±99.05μmol/L和350.86±102.72μmol/L），但未观察到统计学显著差异（分别为318.00±93.75μmol/L和376.44±98.51μmol/L）（P = 0.284，P = 0.161）。关于缺血修饰白蛋白水平，两组之间未观察到统计学显著差异。二硫键水平与宫颈癌分期（r = 0.278，P = 0.029）和总氧化能力水平（r = 0.256，P = 0.046）之间均存在统计学显著正相关。
动态硫醇 - 二硫键稳态可能参与宫颈癌的病理生理机制，未来可能成为早期识别宫颈癌的潜在生物标志物。
