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当 pH 值来拯救时。

When pH comes to the rescue.

机构信息

Department of Microbiology and Molecular Genetics, McGovern Medical School at UTHealth, Houston, United States.

MD Anderson UTHealth Graduate School of Biomedical Sciences, University of Texas, Houston, United States.

出版信息

Elife. 2020 Sep 11;9:e62022. doi: 10.7554/eLife.62022.

DOI:10.7554/eLife.62022
PMID:32915136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7486117/
Abstract

In starving yeast exposed to thermal stress, a transient drop in intracellular pH helps to trigger the heat shock response.

摘要

在遭受热应激的饥饿酵母中，细胞内 pH 的短暂下降有助于触发热休克反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7191/7486117/2562a48cdfc3/elife-62022-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7191/7486117/2562a48cdfc3/elife-62022-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7191/7486117/2562a48cdfc3/elife-62022-fig1.jpg

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本文引用的文献

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Transient intracellular acidification regulates the core transcriptional heat shock response.瞬时细胞内酸化调节核心转录热休克反应。
Elife. 2020 Aug 7;9:e54880. doi: 10.7554/eLife.54880.
2
Cytoplasmic protein misfolding titrates Hsp70 to activate nuclear Hsf1.细胞质蛋白错误折叠使 Hsp70 达到滴定浓度，从而激活核 Hsf1。
Elife. 2019 Sep 25;8:e47791. doi: 10.7554/eLife.47791.
3
Regulation of the Hsf1-dependent transcriptome via conserved bipartite contacts with Hsp70 promotes survival in yeast.通过与 Hsp70 形成保守的二聚体接触来调控 Hsf1 依赖性转录组可促进酵母的存活。
J Biol Chem. 2019 Aug 9;294(32):12191-12202. doi: 10.1074/jbc.RA119.008822. Epub 2019 Jun 25.
4
Protein Phase Separation as a Stress Survival Strategy.蛋白质液-液相分离作为一种应激生存策略。
Cold Spring Harb Perspect Biol. 2019 Jun 3;11(6):a034058. doi: 10.1101/cshperspect.a034058.
5
Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response.Hsf1 和 Hsp70 构成了一个双组分反馈回路，调节酵母热休克反应。
Elife. 2018 Feb 2;7:e31668. doi: 10.7554/eLife.31668.
6
Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response.应激触发的相分离是一种适应性的、经过进化调整的反应。
Cell. 2017 Mar 9;168(6):1028-1040.e19. doi: 10.1016/j.cell.2017.02.027.
7
Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation.热休克期间伴侣蛋白开关和磷酸化对热休克因子1的动态调控
Elife. 2016 Nov 10;5:e18638. doi: 10.7554/eLife.18638.
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Reversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat Stress.内源性蛋白质的可逆、特异性、活性聚集体在热应激时组装形成。
Cell. 2015 Sep 10;162(6):1286-98. doi: 10.1016/j.cell.2015.08.041.
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Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system.热激反应和蛋白伴侣的生物学：芽殖酵母（酿酒酵母）作为模式生物系统。
Microbiol Mol Biol Rev. 2012 Jun;76(2):115-58. doi: 10.1128/MMBR.05018-11.
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Similar dose response of heat shock protein synthesis and intracellular pH change in yeast.酵母中热休克蛋白合成与细胞内pH变化的相似剂量反应。
Exp Cell Res. 1985 Jul;159(1):252-6. doi: 10.1016/s0014-4827(85)80054-9.