Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Pharmacol Ther. 2020 Dec;216:107671. doi: 10.1016/j.pharmthera.2020.107671. Epub 2020 Sep 8.
Microbial infections have significantly increased over the last decades, and the mortality rates remain unacceptably high. The emergence of new resistance patterns and the spread of new viruses challenge the eradication of infectious diseases. The declining efficacy of antimicrobial drugs has become a global public health problem. Natural products derived from natural sources, such as plants, animals, and microorganisms, have significant efficacy for the treatment of infectious diseases accompanied by less adverse effects, synergy, and ability to overcome drug resistance. As the Chinese female scientist Youyou Tu received the Nobel Prize for the antimalarial drug artemisinin, antimicrobial drugs developed from Traditional Chinese Medicine are expected to receive increasing attention again. This review summarizes the antimicrobial agents derived from natural products approved for nearly 20 years and describes their efficacy and mode of action. The aim of this unit is to review the current status of antimicrobial drugs from natural products in order to increase the value of natural products as a source of novel drug candidates for infectious diseases.
微生物感染在过去几十年中显著增加，死亡率仍然高得不可接受。新的耐药模式的出现和新病毒的传播挑战着传染病的消除。抗菌药物疗效的下降已成为一个全球性的公共卫生问题。源自天然来源的天然产物，如植物、动物和微生物，在治疗传染病方面具有显著疗效，同时不良反应较少、具有协同作用且能够克服耐药性。由于中国女科学家屠呦呦因抗疟药物青蒿素获得诺贝尔奖，预计来自中药的抗菌药物将再次受到越来越多的关注。本综述总结了近 20 年来批准的源自天然产物的抗菌药物，并描述了它们的疗效和作用模式。本单元的目的是回顾天然产物来源的抗菌药物的现状，以提高天然产物作为传染病新型药物候选物的价值。
