Wang Chunyan, Wang Shuli, Pan Hong, Min Lingli, Zheng Huili, Zhu Huang, Liu Gang, Yang Weizhong, Chen Xinyu, Hou Xu
State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Collaborative Innovation Center of Chemistry for Energy Materials, Xiamen University, Xiamen 361005, China.
Sci Adv. 2020 Sep 4;6(36). doi: 10.1126/sciadv.abb4700. Print 2020 Sep.
Catheters are indispensable medical devices that are extensively used in daily medical treatment. However, existing catheter materials continue to encounter many problems, such as thrombosis, single functionality, and inadaptability to environmental changes. Inspired by blood vessels, we develop a self-adaptive liquid gating membrane-based catheter with anticoagulation and positionally drug release properties. Our multifunctional liquid gating membrane-based catheter significantly attenuates blood clot formation and can be used as a general catheter design strategy to offer various drugs positionally releasing applications to comprehensively enhance the safety, functionality, and performance of medical catheters' materials.
导管是日常医疗中广泛使用的不可或缺的医疗器械。然而，现有的导管材料仍面临许多问题，如血栓形成、功能单一以及对环境变化的不适应性。受血管启发，我们开发了一种具有抗凝和定位药物释放特性的基于自适应液体门控膜的导管。我们的基于多功能液体门控膜的导管显著减少了血栓形成，并且可以作为一种通用的导管设计策略，提供各种定位释放药物的应用，以全面提高医用导管材料的安全性、功能性和性能。
