Keeney G L, Banks P M, Linscheid R L
Arch Dermatol. 1988 Jul;124(7):1074-6. doi: 10.1001/archderm.124.7.1074.
Subungual keratoacanthoma (SUKA) is an uncommon and clinically distinctive tumor of the nail bed. It can easily be confused with well-differentiated subungual squamous cell carcinoma. Distinguishing features of SUKA include pain, rapid growth, and early underlying bony destruction. Unlike keratoacanthomas arising from sun-exposed skin, SUKAs seldom resolve spontaneously and are more locally destructive. Of 18 cases reported in the literature, five patients have developed recurrent disease, all within five months of the initial surgery. We describe a patient with SUKA initially treated by curettage followed two days later by a conservative amputation that revealed conspicuous residual keratoacanthoma. The deep, burrowing tendency of SUKA and the intimate association with underlying bone may explain the reported tendency for recurrence after curettage.
甲下角化棘皮瘤（SUKA）是一种罕见的、临床上具有独特特征的甲床肿瘤。它很容易与高分化的甲下鳞状细胞癌相混淆。SUKA的鉴别特征包括疼痛、生长迅速和早期骨质破坏。与暴露于阳光下的皮肤发生的角化棘皮瘤不同，SUKA很少自行消退，且具有更强的局部破坏性。在文献报道的18例病例中，有5例患者出现了复发性疾病，均在初次手术后5个月内复发。我们描述了一名SUKA患者，最初采用刮除术治疗，两天后进行了保守性截肢，结果显示有明显的残留角化棘皮瘤。SUKA的深部浸润倾向以及与下方骨骼的密切关联，可能解释了刮除术后复发的报道倾向。
