Göktay Fatih, Kaynak Emre, Güneş Pembegül, Yaşar Şirin, Küçükodacı Zafer, Aytekin Sema
Department of DermatologyUniversity of Health Sciences, Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey.
Department of Pathology, University of Health Sciences, Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey.
Skin Appendage Disord. 2017 Jan;2(3-4):92-96. doi: 10.1159/000449064. Epub 2016 Sep 10.
Subungual keratoacanthoma (SUKA) is a rare form of keratoacanthoma, with the majority of the lesions appearing as rapidly growing, painful hyperkeratotic masses located under the distal nail plate of the thumb. In some cases, SUKA causes damage to the underlying bone. The first case presented here was treated by surgical excision alone, and human papilloma virus (HPV) type 6 was detected in the tissue samples. The second case was treated by surgical excision plus curettage; however, HPV was not detected, and tumor cells were not found in the curettage material. There was near complete improvement in both the clinical appearance and the distal phalanx destruction, with no recurrence at the final follow-up in either patient (30 and 14 months, respectively). Overall, simple excision alone or in combination with curettage seemed to be sufficient in the treatment of SUKA; however, the etiopathogenetic role of HPV in SUKA remains controversial, as in its classical form.
甲下角化棘皮瘤（SUKA）是角化棘皮瘤的一种罕见形式，大多数病变表现为位于拇指远端甲板下迅速生长的、疼痛性角化过度肿块。在某些情况下，SUKA会对其下方的骨骼造成损害。此处呈现的首例病例仅通过手术切除进行治疗，在组织样本中检测到6型人乳头瘤病毒（HPV）。第二例病例采用手术切除加刮除术进行治疗；然而，未检测到HPV，且在刮除物中未发现肿瘤细胞。两例患者的临床表现和远端指骨破坏均几乎完全改善，在最终随访时（分别为30个月和14个月）均无复发。总体而言，单纯切除或联合刮除术似乎足以治疗SUKA；然而，与经典形式一样，HPV在SUKA中的病因学作用仍存在争议。
