一项单盲随机试验，比较1.0%肾上腺素与0.1%双特戊酰肾上腺素（丙美卡因）治疗开角型青光眼和高眼压症的效果。
A single-blind randomised trial comparing adrenaline 1.0% with dipivalyl epinephrine (propine) 0.1% in the treatment of open-angle glaucoma and ocular hypertension.
作者信息
Mills K B, Jacobs N A
机构信息
Manchester Royal Eye Hospital.
出版信息
Br J Ophthalmol. 1988 Jun;72(6):465-8. doi: 10.1136/bjo.72.6.465.
Abstract
The results of this single-blind randomised trial comparing adrenaline 1% with dipivalyl epinephrine (Propine) 0.1% confirm that both have a significant effect in lowering the intraocular pressure in patients with open-angle glaucoma and ocular hypertension, but it is generally insufficient to warrant their use as the first line medical treatment of these two conditions. There was no significant difference between the intraocular lowering effect of the two preparations, and 60% of patients receiving Propine and 66% of those receiving adrenaline noted side effects.
摘要
这项比较1%肾上腺素与0.1%双特戊酰肾上腺素（丙匹罗卡品）的单盲随机试验结果证实，二者在降低开角型青光眼和高眼压症患者眼压方面均有显著效果，但通常不足以使其成为这两种病症一线药物治疗的选择。两种制剂的降眼压效果无显著差异，60%接受丙匹罗卡品的患者和66%接受肾上腺素的患者出现了副作用。
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