Timolol and dipivalyl epinephrine combination therapy.

Combination therapy with timolol 0.25% eye drops and dipivalyl epinephrine (DPE) 0.1% eye drops twice daily is an acceptable form of medication for both chronic simple glaucoma and ocular hypertension. A group of eighteen patients using this combination therapy have been followed up for a period of two years with satisfactory control of intraocular pressure in the majority of cases. An additive effect in lowering intraocular pressure when the two drugs were used in combination was confirmed. Two patients developed a sensitivity reaction to DPE and were able to continue on timolol alone. There was a slight rise in the intraocular pressure between the sixth and ninth months of therapy, but following this the mean intraocular pressure was remarkably stable. Patient acceptance of this twice daily regime was excellent and compliance with the drug therapy was also good.