He Jin, Li Da-Wei, He Feng-Li, Liu Yang-Yang, Liu Ya-Li, Zhang Chen-Yan, Ren Fuzeng, Ye Ya-Jing, Deng Xu-Dong, Yin Da-Chuan
School of Life Sciences, Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an 710072, PR China; Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, PR China; School of Power and Mechanical Engineering, Wuhan University, Wuhan 430072, PR China.
School of Life Sciences, Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an 710072, PR China.
Mater Sci Eng C Mater Biol Appl. 2020 Dec;117:111295. doi: 10.1016/j.msec.2020.111295. Epub 2020 Jul 24.
Zinc is a biodegradable metal, which exhibits more moderate biodegradability than magnesium and iron, so that it has great application potential in the field of biomedical materials. Alloying of zinc and iron may lead to producing a new type of implant material Zn-Fe alloy, which might be able to meet the requirements for a moderate degradation rate. However, due to the huge difference in the melting point between zinc and iron, the preparation of Zn-Fe alloy is quite challenging and hence rarely reported. In this study, we show that Zn-Fe alloys can be successfully prepared by electrodeposition technology. The microstructures, composition, degradation properties and biocompatibility of the Zn-Fe alloys were systematically studied. The results showed that the content of iron in the alloys ranged from 0 to 8 wt%, depending on the concentration of Fe ions and the current density. In the alloys, the major's phases were η, δ and Г, and they were mainly affected by the ion concentration in the electrolyte. In the in vitro immersion tests, the Zn-Fe alloy ZF2-1 showed the highest immersion corrosion rate, while ZF3-1 showed the highest electrochemical corrosion rate. Moreover, we found that the corrosion rates of the alloys were significantly higher than that of the pure Fe. In the in vivo experiments, we confirmed that the Zn-Fe alloy possessed good biocompatibility. These results demonstrate that the electrodeposition technology is a good method to prepare Zn-Fe alloys, and the Zn-Fe alloys prepared by this method are potentially promising materials for biomedical applications.
锌是一种可生物降解的金属，其生物降解性比镁和铁更为适中，因此在生物医学材料领域具有巨大的应用潜力。锌与铁合金化可能会产生一种新型植入材料锌铁合金，它或许能够满足适中降解速率的要求。然而，由于锌和铁的熔点差异巨大，锌铁合金的制备颇具挑战性，因而鲜有报道。在本研究中，我们表明通过电沉积技术能够成功制备锌铁合金。对锌铁合金的微观结构、成分、降解性能和生物相容性进行了系统研究。结果表明，合金中铁的含量在0至8wt%之间，这取决于铁离子浓度和电流密度。在合金中，主要相为η、δ和Г，它们主要受电解液中离子浓度的影响。在体外浸泡试验中，锌铁合金ZF2-1表现出最高的浸泡腐蚀速率，而ZF3-1表现出最高的电化学腐蚀速率。此外，我们发现合金的腐蚀速率明显高于纯铁。在体内实验中，我们证实锌铁合金具有良好的生物相容性。这些结果表明，电沉积技术是制备锌铁合金的一种良好方法，通过该方法制备的锌铁合金是生物医学应用中具有潜在前景的材料。
