Lu Zheng, He Jintao, Yu Yaxiong, Li Zhicen, Li Zhi, Gong Jian
Department of Pediatric Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070 China.
Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070 China.
Chin Neurosurg J. 2019 Apr 10;5:9. doi: 10.1186/s41016-019-0156-9. eCollection 2019.
Many neurophysiological diseases during infancy stage are associated with the morphology and size of the lateral ventricle. This research aims to measure the normal value range of lateral ventricle volume of normal infant and thus provide basic data for clinical treatment.
By retrospective analysis of magnetic resonance inspection (MRI) cranial image of 165 infants in the Department of Pediatric Neurosurgery, Beijing Tiantan Hospital, the infants were divided into four groups according to their age, including the first group (13 month, = 12), the second group (46 month, = 33), the third group (79 month, = 51), and the fourth group (1012 month, = 69). On Neurosoft image workstation, it can measure the sectional area of the lateral ventricle volume at each layer of axis T2W image and calculate the lateral ventricle volume using the Cavalieri method. Moreover, the correlations between lateral ventricle volume and gender, side difference, and month age were analyzed.
95% confidence interval of total bilateral ventricle volume of normal infant: 11920.2214,266.28 mm for male infant and 9922.2212,263.17 mm for female infant; 95% confidence interval of left side ventricle volume: 6254.727546.94 mm for male infant and 5206.036479.99 mm for female infant; 95% confidence interval of right side ventricle volume: 5041.566743.29 mm for male infant and 4695.005804.40 mm for female infant. The lateral ventricle volume of the male infant was normally larger than that of the female infant ( < 0.05). For both male and female infants, the left side ventricle volume was larger than the right ventricle volume ( < 0.01). There was no significant difference in lateral ventricle volume between infants over 3 months old.
The normal value range of lateral ventricle volume of the infant can be obtained via referring MRI image. The lateral ventricle volume of infant varies upon gender and ventricle side.
婴儿期的许多神经生理疾病与侧脑室的形态和大小有关。本研究旨在测量正常婴儿侧脑室体积的正常范围，从而为临床治疗提供基础数据。
通过回顾性分析北京天坛医院小儿神经外科165例婴儿的磁共振成像（MRI）头颅图像，根据年龄将婴儿分为四组，第一组（13个月，n = 12），第二组（46个月，n = 33），第三组（79个月，n = 51），第四组（1012个月，n = 69）。在Neurosoft图像工作站上，可测量轴位T2W图像各层的侧脑室体积截面积，并采用卡瓦列里法计算侧脑室体积。此外，分析了侧脑室体积与性别、左右侧差异和月龄的相关性。
正常婴儿双侧脑室总体积的95%置信区间：男婴为11920.2214266.28mm，女婴为9922.2212263.17mm；左侧脑室体积的95%置信区间：男婴为6254.727546.94mm，女婴为5206.036479.99mm；右侧脑室体积的95%置信区间：男婴为5041.566743.29mm，女婴为4695.005804.40mm。男婴的侧脑室体积通常大于女婴（P<0.05）。对于男婴和女婴，左侧脑室体积均大于右侧脑室体积（P<0.01）。3个月以上婴儿的侧脑室体积无显著差异。
通过参考MRI图像可获得婴儿侧脑室体积的正常范围。婴儿的侧脑室体积因性别和脑室左右侧而异。
