Manwar Rayyan, Kratkiewicz Karl, Mahmoodkalayeh Sadreddin, Hariri Ali, Papadelis Christos, Hansen Anne, Pillers De-Ann M, Gelovani Juri, Avanaki Kamran
University of Illinois at Chicago, Department of Biomedical Engineering, Chicago, IL, United States.
Barbara Ann Karmanos Cancer Institute, Detroit, MI, United States.
Photoacoustics. 2023 Jul 27;32:100538. doi: 10.1016/j.pacs.2023.100538. eCollection 2023 Aug.
We have developed and optimized an imaging system to study and improve the detection of brain hemorrhage and to quantify oxygenation. Since this system is intended to be used for brain imaging in neonates through the skull opening, i.e., fontanelle, we called it, Transfontanelle Photoacoustic Imaging (TFPAI) system. The system is optimized in terms of optical and acoustic designs, thermal safety, and mechanical stability. The lower limit of quantification of TFPAI to detect the location of hemorrhage and its size is evaluated using in-vitro and experiments. The capability of TFPAI in measuring the tissue oxygenation and detection of vasogenic edema due to brain blood barrier disruption are demonstrated. The results obtained from our experimental evaluations strongly suggest the potential utility of TFPAI, as a portable imaging modality in the neonatal intensive care unit. Confirmation of these findings in-vivo could facilitate the translation of this promising technology to the clinic.
我们开发并优化了一种成像系统，用于研究和改进脑内出血的检测，并对氧合进行量化。由于该系统旨在通过颅骨开口（即囟门）对新生儿进行脑成像，因此我们将其称为经囟门光声成像（TFPAI）系统。该系统在光学和声学设计、热安全性以及机械稳定性方面进行了优化。使用体外和体内实验评估了TFPAI检测出血位置及其大小的量化下限。证明了TFPAI在测量组织氧合以及检测因血脑屏障破坏引起的血管源性水肿方面的能力。我们实验评估获得的结果强烈表明，TFPAI作为新生儿重症监护病房中的一种便携式成像方式具有潜在用途。在体内对这些发现的证实可能会促进这项有前景的技术转化到临床应用。
