Lenahan Cameron, Huang Lei, Travis Zachary D, Zhang John H
Burrell College of Osteopathic Medicine, Las Cruces, NM 88003 USA.
Center for Neuroscience Research, School of Medicine, Loma Linda University, Loma Linda, CA 92324 USA.
Chin Neurosurg J. 2019 Dec 17;5:30. doi: 10.1186/s41016-019-0178-3. eCollection 2019.
Stroke is a devastating disease that occurs when a blood vessel in the brain is either blocked or ruptured, consequently leading to deficits in neurological function. Stroke consistently ranked as one of the top causes of mortality, and with the mean age of incidence decreasing, there is renewed interest to seek novel therapeutic treatments. The Scavenger Receptor Class B type 1 (SR-B1) is a multifunctional protein found on the surface of a variety of cells. Research has found that that SR-B1 primarily functions in an anti-inflammatory and anti-atherosclerotic capacity. In this review, we discuss the characteristics of SR-B1 and focus on its potential correlation with the modifiable risk factors of stroke. SR-B1 likely has an impact on stroke through its interaction with smoking, diabetes mellitus, diet, physical inactivity, obesity, hypercholesterolemia, atherosclerosis, coronary heart disease, hypertension, and sickle cell disease, all of which are critical risk factors in the pathogenesis of stroke.
中风是一种毁灭性疾病，当脑血管被阻塞或破裂时就会发生，从而导致神经功能缺损。中风一直是主要死因之一，随着平均发病年龄的降低，人们对寻求新的治疗方法重新产生了兴趣。B1型清道夫受体（SR-B1）是一种在多种细胞表面发现的多功能蛋白质。研究发现，SR-B1主要具有抗炎和抗动脉粥样硬化的功能。在这篇综述中，我们讨论了SR-B1的特性，并重点关注其与中风可改变风险因素的潜在关联。SR-B1可能通过与吸烟、糖尿病、饮食、缺乏运动、肥胖、高胆固醇血症、动脉粥样硬化、冠心病、高血压和镰状细胞病相互作用而对中风产生影响，所有这些都是中风发病机制中的关键风险因素。
