糖尿病和衰老中的血管生成的代谢调控。
Metabolic Regulation of Angiogenesis in Diabetes and Aging.
机构信息
Department of Cell Biology and Molecular Medicine, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey.
Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan; and.
出版信息
Physiology (Bethesda). 2017 Jul;32(4):290-307. doi: 10.1152/physiol.00039.2016.
Abstract
Impaired angiogenesis and endothelial dysfunction are hallmarks of diabetes and aging. Clinical efforts at promoting angiogenesis have largely focused on growth factor pathways, with mixed results. Recently, a new repertoire of endothelial intracellular molecules critical to endothelial metabolism has emerged as playing an important role in regulating angiogenesis. This review thus focuses on the emerging importance and therapeutic potential of these proteins and of endothelial bioenergetics in diabetes and aging.
摘要
血管生成受损和内皮功能障碍是糖尿病和衰老的标志。促进血管生成的临床努力主要集中在生长因子途径上，但结果喜忧参半。最近，一系列对内皮代谢至关重要的新的内皮细胞内分子被认为在调节血管生成中起着重要作用。因此，本综述重点介绍了这些蛋白质以及内皮生物能量学在糖尿病和衰老中的新出现的重要性和治疗潜力。
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