Ferrari David M, Hoffmann Johanna C, Schön Michael P, Lippert Undine
Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.
Pediatr Dermatol. 2020 Nov;37(6):1063-1067. doi: 10.1111/pde.14349. Epub 2020 Sep 14.
BACKGROUND/OBJECTIVES: Para-phenylenediamine, a dye frequently added to henna tattoos to create the black color, is a potent contact allergen. Severe contact dermatitis may arise within days even after the first application. Our objective was to develop a method for rapid and complete removal of para-phenylenediamine-containing black henna tattoos from the skin, an important problem many physicians are confronted with, but for which no simple method exists.
A database search revealed polyethylene glycol 400, described in removal of ortho-phenylenediamine from contaminated skin. We therefore investigated its use in removal of the structurally related ortholog para-phenylenediamine present in black henna tattoos.
A protocol was established involving repeated cycles of rinsing of the skin with polyethylene glycol 400 solution. In 5 patients, one of whom had already developed a severe blistering contact dermatitis and another a mild erosive dermatitis, black henna tattoos were successfully removed. Removal was completed in a single session of 1 hour or less, depending on tattoo size, with a maximum of 6 rinse cycles.
We provide a simple and safe method for rapid and effective removal of black henna tattoos. This procedure requires no special equipment and can be applied in virtually any setting.
背景/目的：对苯二胺是一种常用于指甲花纹身以形成黑色的染料，是一种强效接触性过敏原。即使是首次使用后数天内也可能引发严重的接触性皮炎。我们的目标是开发一种方法，能快速、彻底地从皮肤上清除含对苯二胺的黑色指甲花纹身，这是许多医生面临的一个重要问题，但目前尚无简单的解决方法。
数据库检索发现聚乙二醇400可用于从受污染皮肤上去除邻苯二胺。因此，我们研究了其在去除黑色指甲花纹身中结构相关的对苯二胺同系物的用途。
建立了一个方案，包括用聚乙二醇400溶液反复冲洗皮肤。5名患者中，1名已出现严重水疱性接触性皮炎，另1名出现轻度糜烂性皮炎，黑色指甲花纹身均成功清除。清除工作在1小时或更短时间内完成，具体取决于纹身大小，最多进行6次冲洗循环。
我们提供了一种简单、安全的方法，可快速有效地清除黑色指甲花纹身。该方法无需特殊设备，几乎可在任何环境中应用。
