Department of Oral Histology and Pathology, Faculty of Dentistry, University of Damascus, Syria.
Dent Med Probl. 2020 Jul-Sep;57(3):227-231. doi: 10.17219/dmp/119855.
Heat shock protein 27 (HSP‑27) is a member of the small-molecular-weight HSP family, the expression of which is increased when cells are exposed to elevated temperatures or any other kinds of stress; it seems that the cellular protective properties this protein demonstrates might also help cancer cells stay immortal. Family members of HSPs are either expressed continuously or controlled inductively, and are present in different subcellular structures.
The aim of this study was to investigate the prognostic value of HSP‑27 expression in the histological grades of oral squamous cell carcinoma (OSCC).
In the present study, HSP‑27 expression was compared immunohistochemically among 30 cases with OSCC (15 men and 15 women), ranging between 22 and 74 years of age (mean age: 48 years). The cases were divided into 3 groups (n = 10) according to the histological grade.
While all grades expressed HSP‑27 in the cancerous epithelial cells, the intensity of expression rose gradually from grade 1 to grade 3 tumors (grade 1 < grade 2 < grade 3). The statistical analysis indicated significant differences between the 3 groups (p = 0.000).
This study has found that HSP‑27 may be used as a marker for the histological grades of OSCC and that its expression may be an indicator of the biological behavior of the tumor.
热休克蛋白 27（HSP-27）是小分子 HSP 家族的成员，当细胞暴露于高温或任何其他类型的应激时，其表达会增加；似乎该蛋白表现出的细胞保护特性也有助于癌细胞保持不死。HSP 的家族成员要么连续表达，要么受诱导控制，并存在于不同的亚细胞结构中。
本研究旨在探讨 HSP-27 表达在口腔鳞状细胞癌（OSCC）组织学分级中的预后价值。
在本研究中，通过免疫组织化学比较了 30 例 OSCC 患者（15 例男性和 15 例女性）中 HSP-27 的表达情况，年龄在 22 岁至 74 岁之间（平均年龄：48 岁）。根据组织学分级将病例分为 3 组（n=10）。
所有分级的癌细胞均表达 HSP-27，但表达强度从 1 级肿瘤逐渐升高至 3 级肿瘤（1 级<2 级<3 级）。统计学分析表明 3 组之间存在显著差异（p=0.000）。
本研究发现，HSP-27 可作为 OSCC 组织学分级的标志物，其表达可能是肿瘤生物学行为的指标。
