Huang Junqing, Huang Yao, Xue Zhenluan, Zeng Songjun
Synergetic Innovation Center for Quantum Effects and Application, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of Ministry of Education, Key Laboratory for Matter Microstructure and Function of Hunan Province, School of Physics and Electronics, Hunan Normal University, Changsha, 410081, PR China.
Synergetic Innovation Center for Quantum Effects and Application, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of Ministry of Education, Key Laboratory for Matter Microstructure and Function of Hunan Province, School of Physics and Electronics, Hunan Normal University, Changsha, 410081, PR China.
Biomaterials. 2020 Dec;262:120346. doi: 10.1016/j.biomaterials.2020.120346. Epub 2020 Sep 3.
The development of multifunctional nanoplatform with combination of tumor microenvironment (TME)-responsive dual T/T magnetic resonance (MR) imaging and synergistically self-enhanced photothermal/photodynamic/chemo-therapy is of significant importance for tumor theranostic, which still remains a great challenge. Herein, a novel hollow mesoporous double-shell CoS@MnO nanoplatform loaded with photodynamic agent of indocyanine green molecules (ICG) and chemotherapy drug of doxorubicin (DOX) was designed for TME responsive dual T/T enhanced MR imaging and synergistically enhanced anti-tumor therapy. The designed nanoplatform with MnO shell can act as a TME-responsive oxygen self-supplied producer to alleviate tumor hypoxia and simultaneously improve photodynamic therapy (PDT) efficiency. Moreover, the TME-induced MnO dissolving and near-infrared (NIR) triggered photothermal nature from CoS shell can further promote the tumor-targeted DOX release, leading to the synergistically improved anti-tumor efficacy. And the simultaneous enhancement in dual T/T MR signal was achieved for highly specific tumor diagnosis. The in vivo and in vitro results confirmed that the designed TME-triggered nanoplatform with synergistic combination therapy presented good biocompatibility, and superior inhibition of tumor growth than monotherapy. This study provides the opportunities of designing intelligent TME-activated nanoplatform for highly specific tumor MR imaging and collaborative self-enhanced tumor therapy.
开发具有肿瘤微环境（TME）响应性双T/T磁共振（MR）成像以及协同自增强光热/光动力/化疗功能的多功能纳米平台对于肿瘤诊疗具有重要意义，然而这仍然是一个巨大的挑战。在此，我们设计了一种新型的中空介孔双壳CoS@MnO纳米平台，其负载了吲哚菁绿分子（ICG）光动力剂和阿霉素（DOX）化疗药物，用于TME响应性双T/T增强MR成像以及协同增强抗肿瘤治疗。所设计的带有MnO壳的纳米平台可作为TME响应性的氧自供应产生器，以缓解肿瘤缺氧并同时提高光动力治疗（PDT）效率。此外，TME诱导的MnO溶解以及CoS壳的近红外（NIR）触发光热性质可进一步促进肿瘤靶向DOX释放，从而协同提高抗肿瘤疗效。并且实现了双T/T MR信号的同时增强，用于高度特异性的肿瘤诊断。体内和体外结果证实，所设计的具有协同联合治疗的TME触发纳米平台具有良好的生物相容性，并且比单一疗法对肿瘤生长具有更优异的抑制作用。本研究为设计用于高度特异性肿瘤MR成像和协同自增强肿瘤治疗的智能TME激活纳米平台提供了机会。
