Department of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, 310015, China.
J Nanobiotechnology. 2024 Jun 15;22(1):335. doi: 10.1186/s12951-024-02629-8.
Manganese (Mn) is widely recognized owing to its low cost, non-toxic nature, and versatile oxidation states, leading to the emergence of various Mn-based nanomaterials with applications across diverse fields, particularly in tumor diagnosis and therapy. Systematic reviews specifically addressing the tumor diagnosis and therapy aspects of Mn-derived biomaterials are lacking. This review comprehensively explores the physicochemical characteristics and synthesis methods of Mn-derived biomaterials, emphasizing their role in tumor diagnostics, including magnetic resonance imaging, photoacoustic and photothermal imaging, ultrasound imaging, multimodal imaging, and biodetection. Moreover, the advantages of Mn-based materials in tumor treatment applications are discussed, including drug delivery, tumor microenvironment regulation, synergistic photothermal, photodynamic, and chemodynamic therapies, tumor immunotherapy, and imaging-guided therapy. The review concludes by providing insights into the current landscape and future directions for Mn-driven advancements in the field, serving as a comprehensive resource for researchers and clinicians.
锰 (Mn) 由于其成本低、毒性低以及多样的氧化态，而被广泛认可，这导致了各种基于锰的纳米材料的出现，这些材料在不同领域都有应用，特别是在肿瘤诊断和治疗方面。专门针对锰衍生生物材料在肿瘤诊断和治疗方面的系统评价还很少。本综述全面探讨了锰衍生生物材料的物理化学特性和合成方法，强调了它们在肿瘤诊断中的作用，包括磁共振成像、光声和光热成像、超声成像、多模态成像和生物检测。此外，还讨论了基于锰的材料在肿瘤治疗应用中的优势，包括药物输送、肿瘤微环境调节、协同光热、光动力和化学动力学治疗、肿瘤免疫治疗以及成像引导治疗。该综述最后对锰在该领域的发展现状和未来方向进行了展望，为研究人员和临床医生提供了一个全面的资源。
