Li A P, Gupta R S, Heflich R H, Wassom J S
Monsanto Company, St. Louis, MO 63167.
Mutat Res. 1988 Jul;196(1):17-36. doi: 10.1016/0165-1110(88)90026-7.
Published literature on the Chinese hamster ovary cell/hypoxanthine guanine phosphoribosyl transferase (CHO/HGPRT) assay from mid-1979 through June 1986 was reviewed and evaluated. Data from the papers considered acceptable include test results on 121 chemicals belonging to 25 chemical classes. A total of 87 chemicals were evaluated positive, 3 negative, and 31 inconclusive. Mutagenicity data on 49 of the 121 chemicals evaluated could also be compared with in vivo animal carcinogenicity data. 40 of the 43 reported animal carcinogens were considered mutagenic. Caprolactam, the only definitive noncarcinogen in the group of 49, was not mutagenic. The CHO/HGPRT assay was concluded to be an appropriate assay system for use in the screening of chemicals for genotoxicity.
对1979年年中至1986年6月间发表的有关中国仓鼠卵巢细胞/次黄嘌呤鸟嘌呤磷酸核糖转移酶（CHO/HGPRT）试验的文献进行了综述和评估。被认为可接受的论文数据包括对属于25个化学类别的121种化学物质的测试结果。共有87种化学物质被评估为阳性，3种为阴性，31种结果不确定。对所评估的121种化学物质中的49种的致突变性数据也可与体内动物致癌性数据进行比较。在报告的43种动物致癌物中，有40种被认为具有致突变性。己内酰胺是这49种物质中唯一确定的非致癌物，它不具有致突变性。结论是，CHO/HGPRT试验是用于筛选化学物质遗传毒性的合适试验系统。
