季节性冠状病毒抗体与 SARS-CoV-2 很少发生交叉反应：来自非洲出生队列的研究结果。
Antibodies to Seasonal Coronaviruses Rarely Cross-React With SARS-CoV-2: Findings From an African Birth Cohort.
机构信息
From the Department of Paediatrics and Child Health, and SA-MRC Unit on Child & Adolescent Health, University of Cape Town and Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
Division of Medical Microbiology and Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
出版信息
Pediatr Infect Dis J. 2021 Dec 1;40(12):e516-e519. doi: 10.1097/INF.0000000000003325.
Abstract
Antibodies to seasonal human-coronaviruses (sHCoV) may cross-protect against SARS-CoV-2. We investigated antibody responses in biobanked serum obtained before the pandemic from infants with polymerase chain reaction-confirmed sHCoV. Among 141 samples with antibodies to sHCoV, 4 (2.8%) were positive for SARS-CoV-2-S1 and 8 (5.7%) for SARS-CoV-2-S2. Antibodies to sHCoV rarely cross-react with SARS-CoV-2 antigens and are unlikely to account for mild pediatric illness.
摘要
针对季节性人类冠状病毒（sHCoV）的抗体可能对 SARS-CoV-2 具有交叉保护作用。我们研究了大流行前从聚合酶链反应确认的 sHCoV 的婴儿的生物库血清中获得的抗体反应。在 141 份具有 sHCoV 抗体的样本中，有 4 份（2.8%）对 SARS-CoV-2-S1 呈阳性，8 份（5.7%）对 SARS-CoV-2-S2 呈阳性。针对 sHCoV 的抗体很少与 SARS-CoV-2 抗原发生交叉反应，不太可能导致儿童轻症疾病。
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