This guideline applies to hospitalized adult non-critically ill (non-ICU) patients in general medicine, surgical, perioperative, short-stay, and OB/GYN areas with Type 1 diabetes (T1DM), Type 2 diabetes (T2DM), stress hyperglycemia, diabetes secondary to medications, prediabetes, and gestational diabetes. The objective is to promote safe, effective glycemic management in hospitalized patients targeting blood glucose (BG) to published goals while preventing hypoglycemia. Approximately 30–35% of admitted patients have diabetes. Hyperglycemia is a well-established risk factor for adverse hospital outcomes. Additionally, hypoglycemia can have deleterious consequences. Safe and effective glucose management is of paramount importance in the hospital. Additionally, a hospital admission is an opportune time to address diabetes control.