Laboratory of Cognitive Neuroscience, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Chemin des Mines 9, 1202 Geneva, Switzerland; Center for Neuroprosthetics, Swiss Federal Institute of Technology (EPFL), Campus Biotech, Geneva, Switzerland.
Berenson-Allen Center for Noninvasive Brain Stimulation, Department of neurology, Beth Israel Deaconess Medical Center, 02215 Boston, MA, USA; Hinda and Arthur Marcus Institute for Aging Research, 02131 Boston, MA, USA; Center for Biomedical Imaging (CIBM), Lausanne, Geneva, Switzerland; Department of Neurology, University of Geneva, 24 Rue Micheli-du-Crest, 1211 Geneva, Switzerland.
Neuroimage. 2020 Dec;223:117370. doi: 10.1016/j.neuroimage.2020.117370. Epub 2020 Sep 12.
Episodic memory (EM) is classically conceived as a memory for events, localized in space and time, and characterized by autonoetic consciousness (ANC) allowing to mentally travel back in time and subjectively relive an event. Building on recent evidence that the first-person visual co-perception of one's own body during encoding impacts EM, we used a scene recognition task in immersive virtual reality (VR) and measured how first-person body view would modulate peri-encoding resting-state fMRI, EM performance, and ANC. Specifically, we investigated the impact of body view on post-encoding functional connectivity in an a priori network of regions related either to EM or multisensory bodily processing and used these regions in a seed-to-whole brain analysis. Post-encoding connectivity between right hippocampus (rHC) and right parahippocampus (rPHC) was enhanced when participants encoded scenes while seeing their body. Moreover, the strength of connectivity between the rHC, rPHC and the neocortex displayed two main patterns with respect to body view. The connectivity with a sensorimotor fronto-parietal network, comprising primary somatosensory and primary motor cortices, correlated with ANC after - but not before - encoding, depending on body view. The opposite change of connectivity was found between rHC, rPHC and the medial parietal cortex (from being correlated with ANC before encoding to an absence of correlation after encoding), but irrespective of body view. Linking immersive VR and fMRI for the study of EM and ANC, these findings suggest that seeing one's own body during encoding impacts the brain activity related to EM formation by modulating the connectivity between the right hippocampal formation and the neocortical regions involved in the processing of multisensory bodily signals and self-consciousness.
情景记忆（EM）被经典地构想为对事件的记忆，这些事件在空间和时间上具有定位性，并以自主意识（ANC）为特征，允许人们在时间上回溯并主观地重新体验事件。基于最近的证据表明，在编码过程中第一人称对自身身体的视觉共感知会影响 EM，我们使用沉浸式虚拟现实（VR）中的场景识别任务，并测量第一人称身体视角将如何调节编码前静息状态 fMRI、EM 表现和 ANC。具体来说，我们研究了身体视角对与 EM 或多感觉身体处理相关的先验区域网络中的后编码功能连接的影响，并在种子到全脑分析中使用了这些区域。当参与者在看到自己身体的同时编码场景时，右侧海马体（rHC）和右侧旁海马体（rPHC）之间的后编码连接增强。此外，rHC、rPHC 和新皮层之间的连接强度相对于身体视角显示出两种主要模式。与感觉运动额顶叶网络的连接，包括初级体感和初级运动皮层，与 ANC 相关，仅在后编码 - 而不是前编码后相关，这取决于身体视角。rHC、rPHC 和内侧顶叶皮层之间发现了相反的连接变化 - 从与前编码时的 ANC 相关变为后编码时的相关性缺失，而与身体视角无关。将沉浸式 VR 和 fMRI 结合起来研究 EM 和 ANC，这些发现表明，在编码过程中看到自己的身体会通过调节右侧海马体形成与参与多感觉身体信号和自我意识处理的新皮层区域之间的连接，从而影响与 EM 形成相关的大脑活动。
